Hypothesis: sex determination and germline formation are committed at the pronucleate stage in mammalian embryos

Edwards, R.G.; Beard, Helen K.
July 1999
MHR: Basic Science of Reproductive Medicine;Jul99, Vol. 5 Issue 7, p595
Academic Journal
Proposes that germline could be allocated by the 4-cell stage and regulated by oocyte polarity, controlled cleavage planes and early transcription of sex-determining genes from pronuclear stages. Germline segregation in early embryos and migration of primordial germ cells; Possible role of the germline segregation in the initiation of gonadal sex differentiation.


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