Multiple Hereditary Exostosis, EXT Genes, and Skeletal Development

Sandell, Linda J.
July 2009
Journal of Bone & Joint Surgery, American Volume;Jul2009 Supplement 4, Vol. 91-A, p58
Academic Journal
The article discusses the inheritance and biology of multiple hereditary exostosis. It relates that the condition is an autosomal dominant inherited disease in which osteochondral growths occur on the periphery of bones. It notes that the genes that cause the disease were called exostosins, the EXT genes, which corresponds to the chromosomal localization on chromosomes 8 and 11. It is noted that advances in molecular genetics offered understanding of the disease.


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