Fluorine microimaging and quantification using nuclear reaction analysis: A tool for validating tissue distribution of positron emission tomography tracers

Devès, G.; Roudeau, S.; Carmona, A.; Lavielle, S.; Gionnet, K.; Déléris, G.; Ortega, R.
July 2009
Applied Physics Letters;7/13/2009, Vol. 95 Issue 2, p023701
Academic Journal
An application of ion beam microprobe analysis has been developed for the quantitative imaging of fluorine compounds in biological samples on a micrometer scale. The difficulty of imaging fluorine at trace level concentration in biological tissues has been addressed by using a combination of nuclear reaction analysis and proton resonant backscattering spectrometry. With this method, the limit of detection of fluorine in thin biological samples can be as low as 3 μg/g. Quantitative imaging of fluorodeoxyglucose distribution, the most widely used tracer for detection of solid tumors by positron emission tomography, is shown as an example of this application.


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