TITLE

Superficial Soft Tissue Sarcomas of the Extremities and Trunk

AUTHOR(S)
Lachenmayer, Anja; Qin Yang; Eisenberger, Claus F.; Boelke, Edwin; Poremba, Christopher; Heinecke, Antje; Ohmann, Christian; Knoefel, Wolfram Trudo; Peiper, Matthias
PUB. DATE
August 2009
SOURCE
World Journal of Surgery;Aug2009, Vol. 33 Issue 8, p1641
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Superficial soft tissue sarcomas (sSTS) are an important and frequent subtype of soft tissue sarcoma (STS). A wider knowledge of this tumor type may lead to better strategies in tumor therapy. An institutional review was performed on all patients with primary sSTS of the extremities and trunk operated on between 1990 and 2003. The medical records of 108 patients with sSTS were analyzed. The local recurrence rate was 11% after a median of 25 (mean 42) months. Metastases occurred in 21 patients (19%), and 79 patients lived without evidence of disease after a mean follow-up of 112 ± 42 months. Mean survival time was 89 months at a cumulative 5-year survival rate of 85%. R0 resection significantly enhanced cumulative survival ( p = .001), as did patient age < 60 years ( p = .002), tumor grading G1 and G2 compared to G3 ( p = .004), absence of positive lymph nodes ( p = .018), and no occurrence of metastases ( p = .001). Tumor size ≤ 5 cm reduced the local recurrence rate significantly ( p = .044). Significant multivariate risk factors for metastases were age ≥ 60 years ( p = .016) and tumor grade G3 ( p = .021). Patients with sSTS who are ≥60 years of age or who have G3 tumors have a high risk of distant metastases. Patients with T2 tumors have an elevated risk for local recurrence. Certainly all patients with sSTS should be in a tight after-care program to allow early diagnosis of local recurrence or distant metastases. Age < 60 years, tumor grade G1/2, no positive regional lymph nodes (N0), and a R0 resection are significant prognostic factors for survival.
ACCESSION #
43265298

 

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