TITLE

Effects of ketoprofen and diclofenac potassium on blood coagulation tests after removal of third molars

AUTHOR(S)
da Graça Naclério-Homem, Maria; Cristina Zindel Deboni, Maria; Rapoport, Abrão; Kei Len Chin, Veronica
PUB. DATE
April 2009
SOURCE
Quintessence International;Apr2009, Vol. 40 Issue 4, p321
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: Nonsteroidal anti-inflammatory drugs inhibit platelet aggregation and increase bleeding time; however, they are required to control pain and swelling following dental surgery. The objective of this study was to evaluate possible changes on blood coagulation tests by using ketoprofen and diclofenac potassium after removal of mandibular third molars. Method and Materials: Fifty-one subjects between 16 and 30 years old, with no history of gastrointestinal disorders or allergy to anti-inflammatory components, were randomly assigned to 2 groups: 27 patients received 50 mg of ketoprofen, and 24 patients received 25 mg of diclofenac potassium. Subjects started the oral medication 2 hours before surgery and continued taking it every 8 hours for 5 days. Blood samples were collected preoperatively and on the final day of the drug regime to evaluate prothrombin time, activated partial thromboplastin time, clot retraction, and platelet count. Results: Student t test for matched pairs did not show a significant difference between pre- and posttreatment variables for both antiinflammatory drugs. Conclusion: These results suggest that the safety of ketoprofen and diclofenac potassium is comparable to their anticoagulation effect.
ACCESSION #
43251672

 

Related Articles

  • NSAID, Manipulation or Both for LBP.  // Internal Medicine Alert;1/15/2008, Vol. 30 Issue 1, p7 

    The article reports on the treatment of acute low back pain relative to non-steroidal anti-inflammatory drug (NSAIDs). It states that NSAIDS used to be considered appropriate first line therapy, but heightened awareness of NSAID potential toxicities mandates that their continued utilization...

  • Origins and impact of the term 'NSAID'. Buer, Jonas // Inflammopharmacology;Oct2014, Vol. 22 Issue 5, p263 

    This article is an historical investigation of the term non- steroidal anti- inflammatory drugs and its acronym NSAIDs. Drug names and categories tend to be taken at face value in everyday practice, as natural categories existing in their own right. The main argument of this article is that the...

  • Effects of diclofenac on periosteal callus maturation in osteotomy healing in an animal model. Krischak, Gert D.; Augat, Peter; Sorg, Tobias; Blakytny, Robert; Kinzl, Lothar; Claes, Lutz; Beck, Alexander // Archives of Orthopaedic & Trauma Surgery;Feb2007, Vol. 127 Issue 1, p3 

    Potential adverse effects of nonsteroidal anti-inflammatory drugs (NSAIDs) on bone metabolism and fracture healing are contradictive to their wide application in post-traumatic treatment. Our objective was to investigate changes to periosteal callus formation with respect to NSAID and central...

  • Symptom control at the end of life. Moretto, Emilia // Pulse;Aug2013, p40 

    The article offers information on the ways and drugs used to control disease symptoms during the end of life stage of patients. It says that nonsteroidal anti-inflammatory agents such as morphine, diclofenac, and benzodiazepines are usually administered to treat pain. It adds that patients with...

  • DICLOFENAC (Topical). GRIFFITH, H. WINTER // Complete Guide to Prescription & Nonprescription Drugs 2012;2011, p314 

    The article presents information on diclofenac, a nonsterioidal anti-inflammatory (NSAID) drug, including its dosage, usage, adverse reactions, side effects, precautions when administering, and possible interaction with other drugs.

  • Effect of Diclofenac on the Levels of Lipoxin A4 and Resolvin D1 and E1 in the Post-ERCP Pancreatitis. Zhao, Xiao-wen; Bao, Jun-jun; Hu, Cui; Ding, Hao; Liu, Xiao-chang; Mei, Qiao; Xu, Jian-ming // Digestive Diseases & Sciences;Dec2014, Vol. 59 Issue 12, p2992 

    Objectives: Acute pancreatitis is one of the most common complications of endoscopic retrograde cholangiopancreatography (ERCP). Numerous studies have shown that administered nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the incidence of acute pancreatitis after ERCP. Little is known,...

  • The Use of Ibuprofen in the Treatment of Postoperative Pain in Dentistry. Jakovljević, Aleksandar; Lazić, Emira; Perunović, Neda; Nedeljković, Nenad // Serbian Dental Journal / StomatoloÅ¡ki Glasnik Srbije;2014, Vol. 61 Issue 3, p134 

    Postoperative pain is common complication after daily dental care. Non-steroidal anti-inflammatory drugs are among most widely prescribed analgesics for management of postoperative pain. The analgesic effect of a non-steroidal anti-inflammatory drug (NSAID) is related to its ability to inhibit...

  • A guide to medicines by effect: mouth and teeth. Cope, Graham // Dental Nursing;Nov2011, Vol. 7 Issue 11, p624 

    The article outlines various medicines that are commonly used to treat conditions that affect the mouth and teeth. Drugs such as nonsteroidal anti-inflammatory agents (NSAIDs) and angiotensin converting enzyme (ACE) inhibitors, and chemotherapeutics can cause patients to develop recurring...

  • COX-2 selective treatment reduces gastrointestinal side effects. Siddall, Rhonda // British Journal of Hospital Medicine (17508460);Sep2010, Vol. 71 Issue 9, p491 

    The article reports on a clinical study which indicated that the cyclo-oxygenase-2 selective non-steroidal anti-inflammatory drug (NSAID) celecoxib is less likely to cause gastrointestinal damage than the combination of a non-selective NSAID and a proton pump inhibitor.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics