Alcohol and cardio-respiratory deaths in Chinese: a population-based case-control study of 32,462 older Hong Kong adults

Schooling, C. Mary; Tai Hing Lam; Sai Yin Ho; Yao He; Kwok Hang Mak; Leung, Gabriel M.
January 2009
BMC Public Health;2009, Vol. 9 Issue 1, p1
Academic Journal
Background: In observational studies moderate alcohol use reduces cardio-respiratory mortality. However observational studies may be biased by many factors including residual confounding by unmeasured differences between moderate alcohol users and other groups or by changes in alcohol use with ill-health and aging. We used two different analytic strategies in an under-studied population, i.e. southern Chinese, to provide an assessment of the specific impact of moderate alcohol use on mortality from ischemic heart disease (IHD) and chronic obstructive pulmonary diseases (COPD). Methods: In a population-based case-control study of all adult deaths in Hong Kong Chinese in 1998, we used adjusted logistic regression to compare alcohol use in decedents aged ≥ 60 years from IHD (2270) and COPD (1441) with 10,320 living and 9043 dead controls (all non-alcohol related deaths). We also examined whether the association of alcohol use with death from IHD or COPD varied with sex or smoking status. Results: Using living controls and adjusted for age, socio-economic status and lifestyle, occasional and moderate alcohol use were generally associated with lower mortality from IHD and COPD. However, using dead controls the protection of occasional and moderate alcohol use appeared to be limited to ever-smokers for IHD (odds ratio (OR) 0.58, 95% confidence interval (CI) 0.46 to 0.73 for moderate compared to never-use in ever-smokers, but OR 1.07, 95% CI 0.76 to 1.50 in never-smokers), and possibly to men for COPD. High alcohol use was associated with lower IHD mortality and possibly with lower COPD mortality. Conclusion: High levels of alcohol use in an older Chinese population were associated with lower IHD mortality. Moderate alcohol use was less consistently protective against IHD mortality. Alcohol use was associated with lower COPD mortality particularly in men, either due to some yet to be clarified properties of alcohol or as the artefactual result of genetic selection into alcohol use in a Chinese population. Given the increasing use of alcohol in China with economic development, other designs and analytic strategies are needed to assess the impact of alcohol in this population, so that an evidence-based public health policy can be formulated.


Related Articles

  • Have a little, says heart. Scarpa, James // Restaurant Business;2/15/97, Vol. 96 Issue 4, p106 

    Focuses on an advisory from the American Heart Association on the health benefits of moderate alcohol consumption in preventing coronary heart disease (CHD). Evidence for a strong dose-response relation between increasing alcohol consumption and decreasing incidence of CHD.

  • Alcohol Use and Mortality from Coronary Heart Disease: The Role of High-Density Lipoprotein Cholesterol. Il Suh; Skaten, B. Jessica; Cutler, Jeffrey A.; Kuller, Lewis H. // Annals of Internal Medicine;6/1/92, Vol. 116 Issue 11, p881 

    Explores the association between alcohol consumption and death from coronary heart disease. Distribution of reported weekly alcohol consumption; Characteristics of participants grouped by alcohol consumption during a trial; Overview of average high-density lipoprotein cholesterol level and...

  • Alcohol consumption and risk of coronary heart disease. Jackson, Rodney; Scragg, Robert; Beaglehole, Robert // BMJ: British Medical Journal (International Edition);7/27/91, Vol. 303 Issue 6796, p211 

    Investigates the link between alcohol consumption and the risk of coronary heart disease in Auckland, New Zealand. Examination fatal and non-fatal coronary heart disease; Differentiation between former drinkers and non-drinkers; Validation of alcohol consumption measures.

  • Biological mechanisms at moderate levels of alcohol consumption that may affect coronary heart... Rankin, James G. // Contemporary Drug Problems;Spring94, Vol. 21 Issue 1, p45 

    Presents a framework for understanding the ways in which various alcohol-related mechanisms might fit into current hypotheses of coronary artery disease (CAD). Lipid infiltration of coronary arteries; Endothelial damage; Positive relationship between alcohol consumption and blood pressure.

  • Mounting Evidence. Dixon, Bernard // BMJ: British Medical Journal (International Edition);7/20/91, Vol. 303 Issue 6795, p193 

    Focuses on the protective effect of regular, moderate alcohol intake on mortality from coronary heart disease. Controversies regarding alcohol research; Use of different methods to assess the effect; Rate of reduction in coronary mortality to regular moderate drinking.

  • The association between alcohol consumption and coronary heart disease. Linden, Belinda // British Journal of Cardiac Nursing;Mar2010, Vol. 5 Issue 3, p150 

    The article focuses on the study regarding the association between alcohol consumption and coronary heart disease of men and women.

  • Moderate drinking not OK? Investor's Business Daily // Investors Business Daily;11/11/2014, pA02 

    While you may have heard that the occasional glass of red wine is good for the heart, only 15% of the population has a certain genotype that can benefit from moderate drinking, said Univ. of Gothenburg researchers. Their study, which examined 618 Swedes with coronary heart disease and 3,000...

  • Mendelian randomisation metaanalysis sheds doubt on protective associations between ‘moderate’ alcohol consumption and coronary heart disease. Chikritzhs, Tanya N.; Naimi, Timothy S.; Stockwell, Tim R.; Liang, Wenbin // Evidence Based Medicine;Feb2015, Vol. 20 Issue 1, p38 

    In this article, the authors comment on a study conducted by researcher M. Holmes and colleagues on mendelian randomization (MR) meta-analysis to know association between low dose alcohol consumption and risk of coronary heart diseases (CHD). Topics discussed includes information on MR,...

  • No protective effect of alcohol consumption on coronary heart disease (CHD) in African Americans: Average volume of drinking over the life course and CHD morbidity and mortality in a U.S. national cohort. Sampos, Christopher; Rehm, Jurgen; Crespo, Carlos; Trevisan, Maurizio // Contemporary Drug Problems;Winter2002, Vol. 29 Issue 4, p805 

    Investigates the association between average volume of drinking and coronary heart disease (CHD) morbidity and mortality in African Americans compared with whites. Use of prospective cohort study; Measurement of alcohol intake with a quantity-frequency measure; Incidence of CHD.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics