Thakur, R.; Sarma, S.; Sharma, B.
July 2009
Indian Journal of Medical Microbiology;Jul2009, Vol. 27 Issue 3, p191
Academic Journal
The biological cause of psychiatric illnesses continues to be under intense scrutiny. Among the various neurotropic viruses, Borna disease virus (BDV) is another virus that preferentially targets the neurons of the limbic system and has been shown to be associated with behavioural abnormalities. Presence of various BDV markers, including viral RNA, in patients with affective and mood disorders have triggered ongoing debate worldwide regarding its aetiopathogenic relationship. This article analyses its current state of knowledge and recent advances in diagnosis in order to prove or refute the association of BDV in causation of human neuropsychiatric disorders. This emerging viral causative association of behavioural disorders, which seems to be inching closer, has implication not only for a paradigm shift in the treatment and management of neuropsychiatric illnesses but also has an important impact on the public health systems.


Related Articles

  • Borna disease virus-specific circulating immune complexes, antigenemia, and free antibodies--the key marker triplet determining infection and prevailing in severe mood disorders. Bode, L.; Reckwald, P.; Severus, W.E.; Stoyloff, R.; Ferszt, R.; Dietrich, D.E.; Ludwig, H. // Molecular Psychiatry;2001, Vol. 6 Issue 4, p481 

    Borna disease virus (BDV), a unique genetically highly conserved RNA virus ( Bornaviridae; Mononegavirales), preferentially targets neurons of limbic structures causing behavioral abnormalities in animals. Markers and virus in patients with affective disorders and schizophrenia have raised...

  • NEWS IN BRIEF.  // Molecular Psychiatry;2000, Vol. 5 Issue 1, p9 

    Summarizes research on neuropsychiatry compiled as of 2000. Borna disease virus in brains of sujects who had neuropsychiatric diseases; Adipostat structure in the arctuate nucleas that can integrate orexigenic and anorexigenic signals.

  • Borna again, starting from the beginning. Carbone, K.M.; Pletnikov, M.V. // Molecular Psychiatry;2000, Vol. 5 Issue 6, p577 

    Comments on the article previously published in 'Molecular Psychiatry' discussing the issue of neurotropic viruses in neuropsychiatry. Role played by neurotropic viruses in neurodevelopmental injury; Insights provided by the development of a model on the neonatal rat infection with the Borna...

  • The neuropsychiatry of the cerebellum - insights from the clinic. Schmahmann, Jeremy D.; Weilburg, Jeffrey B.; Sherman, Janet C. // Cerebellum;Sep2007, Vol. 6 Issue 3, p254 

    A central aspect of the cerebellar cognitive affective syndrome is the dysregulation of affect that occurs when lesions involve the 'limbic cerebellum' (vermis and fastigial nucleus). In this case series we describe neuropsychiatric disturbances in adults and children with congenital lesions...

  • Mood instability: significance, definition and measurement. Broome, M. R.; Saunders, K. E. A.; Harrison, P. J.; Marwaha, S. // British Journal of Psychiatry;Oct2015, Vol. 207 Issue 4, p283 

    Mood instability is common, and an important feature of several psychiatric disorders. We discuss the definition and measurement of mood instability, and review its prevalence, characteristics, neurobiological correlates and clinical implications. We suggest that mood instability has...

  • DEPRESSION AND AGE OF ONSET INCREASE RISK OF SUICIDE ATTEMPT IN KOREANS WITH BIPOLAR DISORDER. Ralat, José // CNS Spectrums: The International Journal of Neuropsychiatric Med;Jul2008, Vol. 13 Issue 7, p555 

    The article reports on the study conducted by researchers of Hallym University College of Medicine on depression and early age of onset of bipolar disorder in South Korea. The researchers believe that there are many predictors of suicide attempt in bipolar disorder patients extracted from...

  • Virology: Bornavirus enters the genome. Feschotte, Cédric // Nature;1/7/2010, Vol. 463 Issue 7277, p39 

    The article reports on the study made by M. Horie and colleagues on non-retroviral viruses, also known as borna disease viruses (BDV), in mammalian evolution. The said virus was a unique kind of virus that infects birds and mammals' neurons by establishing persistent infection in its brain. When...

  • Borna Disease Virus (BDV): Neuropharmacological Effects of a CNS Viral Infection. Solbrig, Marylou V.; Koob, George F. // Current Neuropharmacology;Dec2003, Vol. 1 Issue 4, p341 

    Borna Disease Virus (BDV) is a neurotropic RNA virus worldwide in distribution that causes movement, behavior or cognitive disorders in animal species. Borna Disease the illness ranges from asymptomatic to fatal meningoencephalitis across naturally infected warmblooded (mammalian and bird)...

  • Low avidity of human serum antibodies for Borna disease virus antigens questions their diagnostic value. Allmang, U.; Hofer, M.; Herzog, S.; Bechter, K.; Staeheli, P. // Molecular Psychiatry;2001, Vol. 6 Issue 3, p329 

    Borna disease virus (BDV) can induce neurological disease in animals. Since viral nucleic acid, infectious particles and antibodies recognizing BDV antigens were found at higher frequencies in psychiatric patients than in healthy controls, BDV is suspected to cause psychiatric disorders in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics