TITLE

Restricted usage of the T-cell receptor Vβ repertoire in tonsillitis in association with palmoplantar pustulosis: Investigative reports

AUTHOR(S)
Yamamoto, Toshiyuki; Katayama, Ichiro; Nishioka, Kiyoshi
PUB. DATE
June 1998
SOURCE
Acta Dermato-Venereologica;6/1/1998, Vol. 78 Issue 3, p161
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Focal infections such as chronic tonsillitis or dental caries occasionally play a role in the induction or exacerbation of palmoplantar pustulosis (PPP). Arthro-osteitis is sometimes a complication in severe cases of PPP. To study the effects of bacterial infection on the exacerbation of cutaneous lesions and arthralgia, we investigated the T-cell receptor Vβ repertoire in peripheral blood mononuclear cells (PBMC) and tonsil tissue after tonsillectomy in 4 cases, who had chronic tonsillitis and a history of exacerbation of cutaneous lesions following a sore throat. First, serum levels of interleukin-6 (IL-6) and IL-8 were measured before and after tonsillectomy by enzyme-linked immunosorbent assay (ELISA). Second, 3H-TdR incorporation was used to examine the effects of the culture supernatant on the PBMC of the autologous patients, other PPP patients without tonsillitis and normal controls. T-cell receptor Vβ repertoire was examined by the reverse transcriptase-polymerase chain reaction method. Results showed that IL-8 was significantly high in the serum and abundantly released from tonsillar lymphocytes, which may play a role in the accumulation of neutrophils in lesional skin. T-cell receptors Vβ 6 and 12 were preferentially expressed on tonsillar lymphocytes, and Vβ 4, 7, 9, 17 and 18 were detected relatively frequently. These data suggest that restricted usage of T-cell receptor Vβ subsets may play a crucial role in the induction of tonsillitis associated with PPP.
ACCESSION #
4318222

 

Related Articles

  • One-Off Streptococcal Serologic Testing in Young Children With Recurrent Tonsillitis. Borschmann, Michael E.; Berkowitz, Robert G. // Annals of Otology, Rhinology & Laryngology;May2006, Vol. 115 Issue 5, p357 

    Objectives: Recurrent acute tonsillitis in children under 4 years of age is usually viral, making antibiotic therapy inappropriate and the indication for tonsillectomy uncertain. Identifying those young children with bacterial infections is therefore important. The purpose of this study was to...

  • Human β-Defensins in different states of diseases of the tonsilla palatina. Schwaab, Matthias; Gurr, Andre; Hansen, Stefan; Minovi, Amir M.; Thomas, Jan P.; Sudhoff, Holger; Dazert, S. // European Archives of Oto-Rhino-Laryngology;May2010, Vol. 267 Issue 5, p821 

    Tonsils are believed to play an important role during the development of the immune system. Although diseases of the tonsils like hypertrophy of the tonsil, acute tonsillitis, chronic tonsillitis or peritonsillar abscess are common, little is known about the underlying pathophysiology. Little is...

  • Should we be concerned about diphtheria in the UK? McCluney, N. A.; McKerrow, W. S. // Surgeon (Edinburgh University Press);Aug2004, Vol. 2 Issue 4, p234 

    Diphtheria is a very rare condition in the developed world today with the advent of immunisation. Studies from the populations of England and Wales, however, suggest a recent increase in the number of notified cases.¹ Sore throat due to a tonsillitis is the most common manifestation and can,...

  • Recurrent Group C Streptococcal Tonsillitis in an Adolescent Male Requiring Tonsillectomy. Fulginiti, Vincent A.; Ey, John L.; Ryan, Kenneth J. // Clinical Pediatrics;Dec1980, Vol. 19 Issue 12, p829 

    A 15-year-old boy had repeated episodes of tonsillitis with group C streptococci over a four-month period. The tonsillitis cleared with antibiotic therapy but was followed by a recurrence within a few days. Tonsillectomy resulted in a permanent cure and group C streptococcus was found in the...

  • EFFICACY OF HARIDRA KWATH KAWAL IN MANAGEMENT OF ACUTE TONSILLITIS. YADAV, M.; KADAM, D.; VALHAVANKAR, C.; DOLE, R.; BHADLIKAR, D. // International Journal of Medical & Clinical Research;2012, Vol. 3 Issue 8, p235 

    Aim and Objective: Tonsillitis is inflammation of the tonsils most commonly caused by a viral or bacterial infection whose symptoms include sore throat and fever. A modern medicine has faster relief but it has many side effects and produces toxins inside the body, it needs detoxification....

  • A review of the pathogenesis of adult peritonsillar abscess: time for a re-evaluation. Powell, Emily L.; Powell, Jason; Samuel, Julie R.; Wilson, Janet A. // Journal of Antimicrobial Chemotherapy (JAC);Sep2013, Vol. 68 Issue 9, p1941 

    Objectives To perform a multifactorial exploration of the aetiology of peritonsillar abscess (PTA) in adults, in order to develop greater clinical understanding of the condition and improve management. Design A literature review exploring key pathogens, predisposing host factors and current...

  • Bacterial infections.  // GP: General Practitioner;6/13/2008, p36 

    The article features several bacterial infections. These infections include otitis media, perineal abscess, tonsillitis, infected surgical wound, cellulitis, and urinary tract infection. Otitis media is often experienced by children, and is needed to be treated with antibiotics specially if...

  • Evidence of Bacterial Biofilms among Infected and Hypertrophied Tonsils in Correlation with the Microbiology, Histopathology, and Clinical Symptoms of Tonsillar Diseases. Alasil, Saad Musbah; Omar, Rahmat; Ismail, Salmah; Yusof, Mohd Yasim; Dhabaan, Ghulam N.; Abdulla, Mahmood Ameen // International Journal of Otolaryngology;2013, p1 

    Diseases of the tonsils are becoming more resistant to antibiotics due to the persistence of bacteria through the formation of biofilms. Therefore, understanding the microbiology and pathophysiology of such diseases represent an important step in the management of biofilm-related infections. We...

  • Reduction of group A beta-hemolytic streptococcus pharyngo-tonsillar infections associated with use of the oral probiotic Streptococcus salivarius K12: a retrospective observational study. Gregori, Giuseppe; Righi, Ornella; Risso, Paolo; Boiardi, Goffreda; Demuru, Giovanni; Ferzetti, Anna; Galli, Antonio; Ghisoni, Marco; Lenzini, Sonia; Marenghi, Claudio; Mura, Caterina; Sacchetti, Roberto; Suzzani, Lucia // Therapeutics & Clinical Risk Management;Jan2016, Vol. 12, p87 

    Recurrent pharyngo-tonsillar infections caused by group A beta-hemolytic streptococci (GABHS) occur frequently in young children, and the treatment of these infections contributes substantially to the total current requirement for antibiotic prescribing. Our study goal was to assess through a...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics