Early Detection of Epidermal Dust-like Particles in Experimentally UV-induced Lesions in Patients with Photosensitivity and Lupus Erythematosus

Nyberg, F.; Skoglund, C.; Stephansson, E.
June 1998
Acta Dermato-Venereologica;6/1/1998, Vol. 78 Issue 3, p177
Academic Journal
Dust-like particles, producing a specific fine-speckled, epidermo-subepidermal direct immunofluorescence staining pattern, have been associated mainly with subacute cutaneous lupus erythematosus (LE). Under experimental conditions the appearance of immunoglobulins along the basement membrane in ultraviolet (UV) light-induced lesions has been reported as a late phenomenon. In this study, photoprovocations with UVA and UVB light were carried out in 16 photosensitive patients with discoid (n = 13), subacute cutaneous (n = 2) or systemic LE (n = 1) and serial biopsies from UV-induced lesions were processed for direct immunofluorescence. A specific, fine-speckled epidermal staining was detected within 7 to 14 days after UV provocation in 7/16 of the patients; in the majority of those patients associated with anti-SSA antibodies and discoid LE without systemic manifestations of their disease.


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