Clinical reports: Antiinflammatory properties of cetirizine in a human contact dermatitis model: Clinical evaluation of patch tests is not hampered by antihistamines

Grob, Jean Jacques; Castelain, Michel; Richard, Marie Aleth; Bonniol, Jean Pierre; Beéraud, Valérie; Adhoute, Hertzel; Guillou, Nadia; Bonerandi, Jean Jacques
June 1998
Acta Dermato-Venereologica;6/1/1998, Vol. 78 Issue 3, p194
Academic Journal
The aim of this double-blind, placebo-controlled, randomized, cross-over pilot study was to assess the antiinflammatory properties of cetirizine. A group of 27 patients with a positive patch test to an allergen consecutively received cetirizine 10 mg o.d. or placebo during a 14-day period, respectively. At day 11 of each period, patch testing was performed with the allergen. The image analysis showed a skin reaction significantly reduced under cetirizine (p = 0.03), but the clinical recording and the standardized chromatometry did not show any difference between groups. In the cross-over analysis the results of image analysis were influenced by the period, but this effect disappeared after adjustment of the ambient temperature during the 3 days of the test. These results demonstrate that cetirizine has an impact on the inflammatory process in a clinical model of cell-mediated allergic reaction, although this effect is only detected with a very sensitive technique. They also show that it is useless to stop antihistamines before patch testing, since clinical evaluation of tests is not hampered by a potent antihistamine. Additionally this study suggests that ambient temperature has an influence on the results of tests.


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