TITLE

Psoriatic Keratinocytes Express High Levels of Nerve Growth Factor

AUTHOR(S)
Raychaudhuri, Siba P.; Jiang, Wen-Yue; Farber, Eugene M.
PUB. DATE
May 1998
SOURCE
Acta Dermato-Venereologica;5/1/1998, Vol. 78 Issue 2, p84
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Many investigators have reported proliferation of terminal cutaneous nerves and upregulation of various neuropeptides (substance P, vasoactive intestinal polypeptide, calcitonin gene-related peptide) in psoriatic lesions. Nerve growth factor promotes growth of nerves and causes upregulation of neuropeptides like substance P and calcitonin gene-related peptide. In this study we investigated the expression of nerve growth factor in psoriatic lesions, non-lesional psoriatic skin, lichen planus and normal control skin. Immunoperoxidase staining was applied on cryosections prepared from snap-frozen biopsy specimens. The primary antibody used was a polyclonal anti-NGF-β antibody. Nerve growth factor was detected only in the keratinocytes. In psoriatic tissue the number of keratinocytes per square millimeter of epidermis positive for nerve growth factor was 84.7±46.3 compared to 44.8±29.9, 18.9±11.8 and 7.5±16.9, respectively, in non-lesional psoriatic skin, normal skin and lichen planus. Increased expression of nerve growth factor substantiates larger numbers of terminal cutaneous nerves and upregulations of substance P and calcitonin gene-related peptide in psoriatic lesions. In addition, nerve growth factor is mitogenic to keratinocytes, activates T-lymphocytes and can induce migration of inflammatory cellular infiltrates, histological features characteristic of psoriasis.
ACCESSION #
4318175

 

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