Differential expression of nerve growth factor in Leishmania major murine cutaneous Leishmaniasis

Ahmed, Ahmed Abdelaziz; Nordlind, Klas; Söderström, Stine; Lidén, Sture
May 1998
Acta Dermato-Venereologica;5/1/1998, Vol. 78 Issue 2, p87
Academic Journal
The cross-talk between the immune and nervous systems is becoming an interesting field of research and there is accumulating evidence supporting this notion. In the present study we investigated the levels of nerve growth factor in a murine model of cutaneous leishmaniasis, using a two-site ELISA. Two strains of inbred mice were used for this purpose, namely BALB/c and C57BL/6, genetically susceptible and resistant, respectively, to infection with Leishmania major. This work demonstrates a difference in expression of nerve growth factor in the skin and secondary lymphoid organ microenvironment, as well as in the serum, between these mouse strains. The high nerve growth factor levels in the microenvironment seem to be important and possibly critical for the outcome of the disease. Compared with controls, the resistant strain, C57BL/6, expressed significantly increased nerve growth factor levels in the skin, secondary lymphoid organs and serum at 1 week post-infection, whereas the susceptible strain, BALB/c, showed no change in the skin and a slight increase in the lymphoid organs and serum at this time-point. These high nerve growth factor levels in the early stage of the disease, whether produced directly by the inflammatory cells or indirectly through its induction by other cytokines or both, might indicate a contribution of this neurotrophic factor to differentiation of naive T lymphocytes into either Th[sub 1] or Th[sub 2] subsets that fundamentally govern the disease outcome. The expression of significantly elevated nerve growth factor levels in the skin and lymphoid organs of C57BL/6 at the late studied time points might suggest a role for nerve growth factor in the resolution of the disease process, which is usually evident from 6 weeks post-infection in this model. The high nerve growth factor levels expressed in the skin, lymph nodes and serum of BALB/c at late stages of the disease may be explained as an attempt to counteract the progression and dissemination of the disease. This investigation adds further experimental evidence for an anti-inflammatory effect of nerve growth factor, possibly through its action as a link between the nervous and immune systems.


Related Articles

  • Recurrent American Cutaneous Leishmaniasis. Gangneux, Jean-Pierre; Sauzet, Sylvie; Donnard, Sébastien; Meyer, Nicolas; Cornillet, Anne; Pratlong, Francine; Guiguen, Claude // Emerging Infectious Diseases;Sep2007, Vol. 13 Issue 9, p1436 

    A letter to the editor about a case of recurrent American cutaneous leishmaniasis is presented.

  • Outbreak of Cutaneous Leishmaniasis in Northern Israel. Jacobson, Raymond L.; Eisenberger, Carol L.; Svobodova, Milena; Baneth, Gad; Sztern, Julia; Carvalho, Jorge; Nasereddin, Abedelmajeed; El Fari, Mustafa; Shalom, Uri; Volf, Petr; Votypka, Jan; Dedet, Jean-Pierre; Pratlong, Francine; Schonian, Gabriele; Schnur, Lionel F.; Jaffe, Charles L.; Warburg, Alon // Journal of Infectious Diseases;10/1/2003, Vol. 188 Issue 7, p1065 

    Examines the outbreak of cutaneous leishmaniasis due to Leishmania tropica in the Galilee region of northern Israel. Characterization of parasites from patients and sand flies by isoenzyme electrophoresis; Clinical symptoms; Main vector of the disease.

  • Cutaneous Leishmaniasis, Northern Afghanistan. Reithinger, Richard; Aadil, Khoksar; Hami, Samad; Kolaczinski, Jan // Emerging Infectious Diseases;May2004, Vol. 10 Issue 5, p966 

    Presents a letter to the editor about the incidence of cutaneous leishmaniasis in northern Afghanistan.

  • Leishmania killicki Imported from Tunisian Desert. Maubon, Danièle; Thurot-Guillou, Céline; Ravel, Christophe; Leccia, Marie-Thérèse; Pelloux, Hervé // Emerging Infectious Diseases;Nov2009, Vol. 15 Issue 11, p1864 

    A letter to the editor about a case of chronic cutaneous leishmaniasis (CL) caused by Leishmania killicki after visiting Tunisia is presented.

  • Nerve growth factor may heal corneal ulcers. Josefson, Deborah // BMJ: British Medical Journal (International Edition);05/02/98, Vol. 316 Issue 7141, p1335 

    Focuses on a study which states that the application of eye drops which contains nerve growth factor, can heal corneal ulcers and restore damaged vision. Reference to the study involving 12 patients with 14 neurotrophic corneal ulcers; Relation to corneal healing beginning in 2 to 14 days of...

  • Clearing the Cornea with Nerve Growth Factor. Smith, Ronald E.; Sadun, Alfredo A. // New England Journal of Medicine;04/23/98, Vol. 338 Issue 17, p1222 

    Editorial. Comments on corneal ulceration or keratitis. Reference to the study by Lambiase et al on the healing action of topically applied nerve growth factor; The suggestion there should be more investigations of the basic mechanism by which trophic factors, such as nerve growth factor,...

  • Safety of retroviral gene marking with a truncated NGF receptor. Bonini, C.; Grez, M.; Traversari, C.; Ciceri, F.; Marktel, S.; Ferrari, G.; Dinauer, M.; Sadat, M.; Aiuti, A.; Deola, S.; Radrizzani, M.; Hagenbeek, A.; Apperley, J.; Ebeling, S.; Martens, A.; Kolb, H.J.; Weber, M.; Lotti, F.; Grande, A. // Nature Medicine;Apr2003, Vol. 9 Issue 4, p367 

    Presents a letter to the editor on the safety of retroviral gene marking with a truncated nerve growth factor receptor, published in the journal 'Nature Medicine,' as of April 1, 2003. Safety factors associated with the use of nerve growth factor receptor.

  • Nerve growth factor acts via retinoic acid synthesis to stimulate neurite outgrowth. Corcoran, Jonathan; Maden, Malcolm // Nature Neuroscience;Apr99, Vol. 2 Issue 4, p307 

    Nerve growth factor (NGF) stimulates neurite outgrowth from cultured adult dorsal root ganglia (DRG), and the vitamin A derivative all-trans-retinoic acid (tRA) induces neurite outgrowth from various embryonic sources, including DRG. Are such similarities in effects of NGF and tRA because they...

  • Nitric oxide triggers a switch to growth arrest during differentiation of neuronal cells. Peunova, Natalia; Enikolopov, Grigori // Nature;5/4/1995, Vol. 375 Issue 6526, p68 

    Presents evidence that the cytostatic effect of nerve growth factor (NGF) is mediated by nitric oxide, a second messenger molecule with both para- and autocrine properties that can diffuse freely and act within a restricted volume. Suggestion on nitric oxide synthase acting as a growth arrest...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics