Performance of iterative optoacoustic tomography with experimental data

Jetzfellner, Thomas; Razansky, Daniel; Rosenthal, Amir; Schulz, Ralf; Englmeier, K.-H.; Ntziachristos, Vasilis
July 2009
Applied Physics Letters;7/6/2009, Vol. 95 Issue 1, p013703
Academic Journal
In this letter we experimentally demonstrate the sensitivity and overall performance of iterative correction for light attenuation in optoacoustic tomography as a function of number of iterations and accuracy of the tissue optical properties estimations. Experimental optoacoustic data were obtained by circularly illuminating a tissue-mimicking phantom with a high intensity pulsed near infrared laser and measuring the subsequent acoustic waves using a broadband acoustic hydrophone. We showcase an improvement in image fidelity and quantification due to the iterative inversion but find the method sensitive to the background optical properties and of a diverging behavior when increasing the number of iterations.


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