Secondary immune-mediated thrombocytopenia in dogs naturally infected by Leishmania infantum

Cortese, L.; Sica, M.; Piantedosi, D; Ruggiero, G.; Pero, M. E.; Terrazzano, G.; Mastellone, V.; Ciaramella, P.
June 2009
Veterinary Record: Journal of the British Veterinary Association;6/20/2009, Vol. 164 Issue 25, p778
Academic Journal
Forty-four dogs naturally infected by Leishmania infantum were divided into two groups: 20 thrombocytopenic dogs with fewer than 150 x 109 platelets/I, and 24 non-thrombocytopenlc dogs with more than 200 x 109 platelets/I. Ten clinically healthy dogs were used as controls. A haematological profile was obtained and the dogs' serum was used to assess the presence of platelet-binding IgM and lgG antibodies using a flow cytometry technique. Nineteen of the 20 thrombocytopenic dogs, and 13 of the 24 non-thrombocytopenic dogs had detectable levels of platelet-binding immunoglobulins, but none of the control dogs did so. The differences were significantly different for both IgM and lgG platelet-binding antibodies.


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