Interleukin 17 Production among Patients with American Cutaneous Leishmaniasis

Bacellar, Olívia; Faria, Daniela; Nascimento, Márcia; Cardoso, Thiago M.; Gollob, Kenneth J.; Dutra, Walderez O.; Scott, Phillip; Carvalho, Edgar M.
July 2009
Journal of Infectious Diseases;7/1/2009, Vol. 200 Issue 1, p75
Academic Journal
Interleukin 17 (IL-17) plays a critical role in inflammation and autoimmunity. Very little is known about IL- 17 in protozoa infection. Here, we show that lymphocytes obtained from patients with mucosal leishmaniasis and cutaneous leishmaniasis produce higher levels of IL-17 than do lymphocytes obtained from uninfected control subjects (P < .01). There was a tendency for tissue obtained from patients with mucosal leishmaniasis to contain a higher number of cells expressing IL-17, compared with tissue obtained from patients with cutaneous leishmaniasis, and there was a direct correlation between the number of cells expressing IL-17 and the presence of cellular inflammation at the lesion site (r² = 0.86; P < .001). These data support the role of IL-17 in the pathogenesis of the inflammatory reaction in leishmaniasis.


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