TITLE

Do Amino Acid Biosynthetic Costs Constrain Protein Evolution in Saccharomyces cerevisiae?

AUTHOR(S)
Raiford, Douglas W.; Heizer, Jr., Esley M.; Miller, Robert V.; Akashi, Hiroshi; Raymer, Michael L.; Krane, Dan E.
PUB. DATE
December 2008
SOURCE
Journal of Molecular Evolution;Dec2008, Vol. 67 Issue 6, p621
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Prokaryotic organisms preferentially utilize less energetically costly amino acids in highly expressed genes. Studies have shown that the proteome of Saccharomyces cerevisiae also exhibits this behavior, but only in broad terms. This study examines the question of metabolic efficiency as a proteome-shaping force at a finer scale, examining whether trends consistent with cost minimization as an evolutionary force are present independent of protein function and amino acid physicochemical property, and consistently with respect to amino acid biosynthetic costs. Inverse correlations between the average amino acid biosynthetic cost of the protein product and the levels of gene expression in S. cerevisiae are consistent with natural selection to minimize costs. There are, however, patterns of amino acid usage that raise questions about the strength (and possibly the universality) of this selective force in shaping S. cerevisiae’s proteome.
ACCESSION #
42992812

 

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics