TITLE

Continued use of antipsychotic drugs increased long-term mortality in patients with Alzheimer disease

AUTHOR(S)
Hirsch, Calvin
PUB. DATE
June 2009
SOURCE
ACP Journal Club;6/23/2009, Vol. 150 Issue 6, p6
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article discusses whether continued treatment with antipsychotic drugs (APDs) increase mortality in patients with Alzheimer disease. A randomized placebo-controlled trial was conducted on 165 patients who lived in nursing or residential homes. The intervention, outcomes and patient follow up of the trial are discussed. It was revealed that continued use of antipsychotic drugs increased long-term mortality in patients with Alzheimer disease.
ACCESSION #
42876698

 

Related Articles

  • Rationale and design of the multicentre, randomized, double-blind, placebo-controlled Aliskiren Trial on Acute Heart Failure Outcomes (ASTRONAUT). Gheorghiade, Mihai; Albaghdadi, Mazen; Zannad, Faiez; Fonarow, Gregg C.; B�hm, Michael; Gimpelewicz, Claudio; Botha, Jaco; Moores, Shelley; Lewis, Eldrin F.; Rattunde, Henning; Maggioni, Aldo // European Journal of Heart Failure;Jan2011, Vol. 13 Issue 1, p100 

    Background Hospitalizations for acute heart failure syndromes (AHFS) are associated with high post-discharge mortality and readmission rates in spite of available therapies. Renin�angiotensin�aldosterone system (RAAS) antagonists improve outcomes in outpatients with heart failure (HF)...

  • Systematic meta-review of depot antipsychotic drugs for people with schizophrenia. Adams, Clive E.; Fenton, Mark K. P.; Quraishi, Seema; David, Anthony S. // British Journal of Psychiatry;Oct2001, Vol. 179, p290 

    Background Long-acting depot antipsychotic medication is a widely used treatment for schizophrenia. Aims To synthesise relevant systematic Cochrane reviews. Method The Cochrane Database was searched and summary data were extracted from randomised controlled clinical trials of depots. Results...

  • Pexelizumab for Acute ST-Elevation Myocardial Infarction in Patients Undergoing Primary Percutaneous Coronary Intervention. Armstrong, Paul W.; Granger, Christopher B.; Abrams, Peter X.; Hamm, Christian; Holmes Jr., David; O'Neil, William W.; Todaro, Thomas G.; Vahanian, Alec; Van de Werf, Frans; Al-Khalidi, Hussein; Ardissino, Diego; Aylward, Phil; Betriu, Amadeo; Hochman, Judith; Huber, Kurt; James, Stefan; Lee, Kerry; Mahaffey, Kenneth W.; Moliterno, David; Montalescot, Gilles // JAMA: Journal of the American Medical Association;1/3/2007, Vol. 297 Issue 1, p43 

    This article focuses on a placebo-controlled phase 3 study of the effectiveness of the drug, pexelizumab, as an adjunct to percutaneous transliminal coronary intervention (PCI) in the treatment of patients with acute ST-elevation myocardial infarction. Patients received either placebo or...

  • Long-acting Injectable Antipsychotics in First-episode Schizophrenia. Jeong, Hyun-Ghang; Lee, Moon-Soo // Clinical Psychopharmacology & Neuroscience;Apr2013, Vol. 11 Issue 1, p1 

    Antipsychotic medications are important for the successful management of schizophrenia. Continuous treatment with medication is superior in relapse prevention and non-adherence to antipsychotic medication is associated with a poor clinical outcome. Long-acting injectable antipsychotics (LAIs)...

  • Utility of Two PANSS 5-Factor Models for Assessing Psychosocial Outcomes in Clinical Programs for Persons with Schizophrenia. Jerrell, Jeanette M.; Hrisko, Stephanie // Schizophrenia Research & Treatment;2013, p1 

    Using symptom factors derived from two models of the Positive and Negative Syndrome Scale (PANSS) as covariates, change over time in consumer psychosocial functioning, medication adherence/compliance, and treatment satisfaction outcomes are compared based on a randomized, controlled trial...

  • AKL1, a botanical mixture for the treatment of asthma: a randomised, double-blind, placebo-controlled, cross-over study. Thomas, Michael; Sheran, Jane; Smith, Natalie; Fonseca, Sofia; Lee, Amanda J. // BMC Pulmonary Medicine;2007, Vol. 7, p4 

    Background: Despite effective treatments, asthma outcomes remain suboptimal. Interest exists in complementary therapies, particularly in herbal remedies for asthma treatment, currently with inconclusive evidence of efficacy. The encapsulated botanical mixture AKL1 has anecdotal evidence of...

  • Coenzyme Q10 and cardiovascular disease. Hume, Anne L. // Pharmacy Today;Feb2013, Vol. 19 Issue 2, p25 

    The article offers information on the study conducted by doctor Domnica Fotino and colleagues concerning the effect of coenzyme Q10 supplements on the outcomes of heart failure (HF). It mentions that the study examines the randomized placebo-controlled studies concerning the supplement....

  • Intravesical Ropivacaine as a Novel Means of Analgesia Post-Robot-Assisted Radical Prostatectomy: A Randomized, Double-Blind, Placebo-Controlled Trial. Fuller, Andrew; Vanderhaeghe, Leanne; Nott, Linda; Martin, Paul R; Pautler, Stephen E. // Journal of Endourology;Mar2013, Vol. 27 Issue 3, p313 

    Purpose: This study evaluates the safety and efficacy of intravesical ropivacaine as part of a mulitimodal approach to the provision of analgesia after robot-assisted radical prostatectomy (RARP). Patients and Methods: In this double-blind, placebo-controlled trial, 40 patients who were...

  • A multi-centre randomised double-blind placebo-controlled trial to evaluate the value of a single bolus intravenous alfentanil in CT colonography. Boellaard, Thierry N.; Van der Paardt, Marije P.; Hollmann, Markus W.; Eberl, Susanne; Peringa, Jan; Schouten, Lex J.; Kavaliauskiene, Giedre; Runge, Jurgen H.; Tielbeek, Jeroen A. W.; Stoker, Jaap // BMC Gastroenterology;2013, Vol. 13 Issue 1, p1 

    Background: Pain is common during colonic insufflation required for CT colonography. We therefore evaluate whether a single intravenous alfentanil bolus has a clinically relevant analgesic effect compared with placebo in patients undergoing CT colonography. Methods: A prospective multi-centre...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics