Hepatitis C virus lymphotropism and peculiar immunological phenotype: Effects on natural history and antiviral therapy

Conca, Paolo; Tarantino, Giovanni; Salupere, Riina; Wirth, Stefan; De Moura, Miguel C.
May 2009
World Journal of Gastroenterology;5/21/2009, Vol. 15 Issue 19, p2305
Academic Journal
Hepatitis C virus (HCV) has been recognized to be both a hepato- and lymphotropic virus. HCV lymphotropism represents an essential lap in the pathogenesis of virus-related autoimmune and lymphoproliferative disorders, ranging from clonal expansion of B-cells with organ- and non-organ-specific autoantibody production up to overt non-Hodgkin's lymphoma along a continuous step-by-step model of B-cell lymphomagenesis, where the intermediated mixed cryoglobulinemia could be considered as a stage of suppressible antigen-driven lymphoproliferation. HCV infection of lymphoid cells could set up privileged reservoirs able to interfere with the host viral clearance efficiency and may be implicated in viral recurrence after apparently successful antiviral therapy. The HCV long-lasting extrahepatic replicative state generates an abnormal systemic immunological response, easily detectable by searching simple laboratory and clinical parameters, mainly represented by vasculitis-like skin features and hypocomplementemia. The presence or absence of this hypersensitivity pattern seems to correlate with the antiviral response and could be identified as a novel immunological cofactor. Further research is required to fully verify the real impact on therapeutic choice/regimen.


Related Articles

  • HAART and Ribavirin: Mitochondrial Toxicity. Kemper, Carol // Infectious Disease Alert;Sep2010, Vol. 29 Issue 12, p143 

    The article discusses a study of patients with HIV and hepatitis C virus (HIV-HCV) coinfection treated with highly active antiretroviral therapy (HAART) in combination with pegylated interferon alfa and ribavirin for HCV. It references a study by T. Reiberger et al in the "Journal of Infectious...

  • Incident Hepatitis C Virus Infection in Men Who Have Sex With Men: A Prospective Cohort Analysis, 1984–2011. Witt, Mallory D.; Seaberg, Eric C.; Darilay, Annie; Young, Stephen; Badri, Sheila; Rinaldo, Charles R.; Jacobson, Lisa P.; Detels, Roger; Thio, Chloe L. // Clinical Infectious Diseases;Jul2013, Vol. 57 Issue 1, p77 

    In the United States, incident hepatitis C among men who have sex with men has been ongoing since at least 1984. Risk factors included unprotected receptive anal intercourse with multiple partners, HIV infection, and lower CD4 T-cell count among HIV-infected men.Background Prospective...

  • No association of oral lichen planus and hepatitis C virus infection in central Germany. Remmerbach, Torsten; Liese, Jan; Krause, Sarah; Schiefke, Ingolf; Schiefke, Franziska; Maier, Melanie; Liebert, Uwe // Clinical Oral Investigations;Jan2016, Vol. 20 Issue 1, p193 

    Objectives: Co-occurrence of oral lichen planus (OLP) and chronic hepatitis C virus (HCV) infection suggests a strong association, but the relation between mucocutaneus, autoimmune lichen planus and HCV infection remains unclear. In areas with higher prevalence of HCV infection in general...

  • Extrahepatic Manifestations and Autoantibodies in Patients with Hepatitis C Virus Infection. Himoto, Takashi; Masaki, Tsutomu // Clinical & Developmental Immunology;2012, p1 

    Patients with chronic hepatitis C virus (HCV) infection frequently have many extrahepatic manifestations, as persistent HCV infection often triggers lymphoproliferative disorders and metabolic abnormalities. These manifestations primarily include autoimmune disorders such as cryoglobulinemia,...

  • The positivity of rheumatoid factor and anti-cyclic citrullinated peptide antibody in nonarthritic patients with chronic hepatitis c infection. Örge, E.; Çefle, A.; Yazıcı, Ayten; Gürel-Polat, N.; Hulagu, S. // Rheumatology International;Feb2010, Vol. 30 Issue 4, p485 

    Chronic hepatitis C virus (HCV) has extrahepatic autoimmune properties and a variety of autoantibodies were found in patients with HCV. Patients with HCV infection may have rheumatic symptoms and signs, and 50–70% of the cases may contain rheumatoid factor (RF). The increased prevalence...

  • Hepatitis C and HIV co-infection. Leen, C. L. S. // International Journal of STD & AIDS;May2004, Vol. 15 Issue 5, p289 

    HIV accelerates progression of hepatitis C virus (HCV)-related liver disease. There are conflicting data on the effect of HCV on the risk of HIV progression and CD4 response to highly active antiretroviral therapy (HAART). Long-term prospective cohort studies are clearly required to resolve...

  • Impact of human immunodeficiency virus infection on the course of hepatitis C virus infection: A meta-analysis. Li-Ping Deng; Xi-En Gui; Yong-Xi Zhang; Shi-Cheng Gao; Rong-Rong Yang; Rodriguez-Torres, Maribel // World Journal of Gastroenterology;2/28/2009, Vol. 15 Issue 8, p996 

    AIM: To analyze the influence of human immunodeficiency virus (HIV) infection on the course of hepatitis C virus (HCV) infection. METHODS: We performed a meta-analysis to quantify the effect of HIV co-infection on progressive liver disease in patients with HCV infection. Published studies in the...

  • Evolution of cellular immune responses to hepatitis C virus during antiretroviral therapy and its clinical implications. Diepolder, Helmut; Gruener, Norbert // Gut;Sep2010, Vol. 59 Issue 9, p1167 

    The article discusses the evolution of cellular immune responses to hepatitis C virus (HCV) during antiretroviral therapy and its clinical implications. The association between the clinical outcome of hepatitis C in human immunodeficiency virus (HIV)-negative patients with HCV-specific CD4+...

  • Virological effectiveness and CD4+ T-cell increase over early and late courses in HIV infected patients on antiretroviral therapy: focus on HCV and anchor class received.  // AIDS Research & Therapy;2012, Vol. 9, p18 

    The article offers information regarding a study which aimed to explore the effects of Hepatitis C Virus (HCV) co-infection on virological effectiveness and on CD4+ T-cell recovery in patients with an early and sustained virological response after Highly Active Antiretroviral Therapy (HAART). As...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics