TITLE

Olive oil consumption and non-alcoholic fatty liver disease

AUTHOR(S)
Assy, Nimer; Nassar, Faris; Nasser, Gattas; Grosovski, Maria; Wisse, Eddie
PUB. DATE
April 2009
SOURCE
World Journal of Gastroenterology;5/21/2009, Vol. 15 Issue 15, p1809
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The clinical implications of non-alcoholic fatty liver diseases (NAFLD) derive from their potential to progress to fibrosis and cirrhosis. Inappropriate dietary fat intake, excessive intake of soft drinks, insulin resistance and increased oxidative stress results in increased free fatty acid delivery to the liver and increased hepatic triglyceride (TG) accumulation. An olive oil-rich diet decreases accumulation of TGs in the liver, improves postprandial TGs, glucose and glucagon-like peptide-1 responses in insulin-resistant subjects, and upregulates glucose transporter-2 expression in the liver. The principal mechanisms include: decreased nuclear factor-kappaB activation, decreased low-density lipoprotein oxidation, and improved insulin resistance by reduced production of inflammatory cytokines (tumor necrosis factor, interleukin-6) and improvement of jun N-terminal kinase-mediated phosphorylation of insulin receptor substrate-1. The beneficial effect of the Mediterranean diet is derived from monounsaturated fatty acids, mainly from olive oil. In this review, we describe the dietary sources of the monounsaturated fatty acids, the composition of olive oil, dietary fats and their relationship to insulin resistance and postprandial lipid and glucose responses in non-alcoholic steatohepatitis, clinical and experimental studies that assess the relationship between olive oil and NAFLD, and the mechanism by which olive oil ameliorates fatty liver, and we discuss future perspectives.
ACCESSION #
42834284

 

Related Articles

  • Alleviation of insulin resistance and liver damage by oral administration of Imm124-E is mediated by increased Tregs and associated with increased serum GLP-1 and adiponectin: results of a phase I/II clinical trial in NASH. Mizrahi, Meir; Shabat, Yehudit; Ya'acov, Ami Ben; Lalazar, Gadi; Adar, Tomer; Wong, Victor; Muller, Brian; Rawlin, Grant; Ilan, Yaron // Journal of Inflammation Research;2012 Part 2, Vol. 5, p141 

    Background: Nonalcoholic steatohepatitis (NASH) is considered to be part of the nonalcoholic fatty liver disorders and its incidence is increasing. Imm124-E (Immuron Ltd, Melbourne, Australia), containing hyperimmune bovine colostrum, has been shown to exert an immunomodulatory effect and to...

  • Determinants of Glucose Intolerance in Subjects with Non-Alcoholic Fatty Liver Disease. Czupryniak, Leszek; Szymanska-Garbacz, Elektra; Saryusz-Wolska, Malgorzata; Pawlowski, Maciej; Jablkowski, Maciej; Bialkowska, Jolanta; Borkowska, Anna; Omulecka, Aleksandra; Loba, Jerzy // Diabetes;Jun2007 Supplement 1, Vol. 56, pA679 

    Non-alcoholic fatty liver disease (NAFLD) is associated with insulin resistance and is considered a risk factor for the development of diabetes. However, it is not clear why only a fraction of subjects with NAFLD become diabetic. The aim of the study was to identify factors predisposing to the...

  • Liraglutide reduces lipid accumulation in steatotic L-02 cells by enhancing autophagy. SHI-WEI ZHOU; MAN ZHANG; MIN ZHU // Molecular Medicine Reports;2014, Vol. 10 Issue 5, p2351 

    Simple hepatic steatosis is the early stage of non-alcoholic fatty liver disease and is recognized as a benign process. Previous studies show that glucagon-like peptide-1 has great potential in improving hepatic steatosis. Recent data have revealed that inhibiting autophagy exacerbates lipid...

  • Exendin-4 attenuates endoplasmic reticulum stress through a SIRT1-dependent mechanism. Lee, Jinmi; Hong, Seok-Woo; Park, Se; Rhee, Eun-Jung; Park, Cheol-Young; Oh, Ki-Won; Park, Sung-Woo; Lee, Won-Young // Cell Stress & Chaperones;Sep2014, Vol. 19 Issue 5, p649 

    Accumulation of excess hepatic lipids contributes to insulin resistance and liver disease associated with endoplasmic reticulum (ER) stress. Exendin-4 is an agonist of the glucagon-like peptide 1 receptor and plays a role in improving insulin resistance and liver disease by increasing silent...

  • Esteatosis hepática, esteatohepatitis y marcadores de lesión hepática. Barba Evia, José Roberto // Revista Mexicana de Patologia Clinica;oct-dic2008, Vol. 55 Issue 4, p216 

    Nonalcohlic fatty liver disease affects a large proportion of the population. Is a clinicopathological entity characterized by the development of histological changes in the liver that are nearly identical to those induced by excessive alcohol intake, but in the absence of intake of this....

  • Liraglutide Improves Non-alcoholic Steatohepatitis. Kuritzky, Louis // Internal Medicine Alert;7/15/2016, Vol. 38 Issue 13, p7 

    The article presents the results of a study conducted by researcher M. J. Armstrong and colleagues regarding the safety and efficacy of liraglutide for the treatment of non-alcoholic steatohepatitis.

  • Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease. Park, Hyohun; Shima, Toshihide; Yamaguchi, Kanji; Mitsuyoshi, Hironori; Minami, Masahito; Yasui, Kohichiroh; Itoh, Yoshito; Yoshikawa, Toshikazu; Fukui, Michiaki; Hasegawa, Goji; Nakamura, Naoto; Ohta, Mitsuhiro; Obayashi, Hiroshi; Okanoue, Takeshi // Journal of Gastroenterology;Jan2011, Vol. 46 Issue 1, p101 

    Background: Hyperlipidemia, insulin resistance, and oxidative stress can heavily contribute to the initiation and progression of nonalcoholic fatty liver disease (NAFLD). Currently, there is no established treatment for this disease. Recently, several studies have shown that ezetimibe (EZ), a...

  • Preventive effects of chronic exogenous growth hormone levels on diet-induced hepatic steatosis in rats. Ying Qin; Ya-ping Tian // Lipids in Health & Disease;2010, Vol. 9, p78 

    Background: Non-alcoholic fatty liver disease (NAFLD), which is characterized by hepatic steatosis, can be reversed by early treatment. Several case reports have indicated that the administration of recombinant growth hormone (GH) could improve fatty liver in GH-deficient patients. Here, we...

  • Deregulation of FoxO1 and Insulin Signaling Associated with Steatohepatitis and Hepatic Insulin Resistance. Valenti, Luca; Rametta, Raffaela; Dongiovanni, Paola; Roviaro, Giancarlo; Maggioni, Marco; Fargion, Silvia // Diabetes;Jun2007 Supplement 1, Vol. 56, pA345 

    Nonalcoholic fatty liver disease (NAFLD), affecting 15-20% of the population, is characterized by hepatic insulin resistance, dyslipidemia, and early vascular damage, which are more marked in the presence of steatohepatitis (NASH). Aim was to evaluate the role of FoxO1, transcriptional mediator...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics