TITLE

Circulating markers for endocrine tumours of the gastroenteropancreatic tract

AUTHOR(S)
Ardill, Joy E. S.
PUB. DATE
November 2008
SOURCE
Annals of Clinical Biochemistry;Nov2008, Vol. 45 Issue 6, p539
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The diffuse endocrine system (DES) includes a wide range of secretory cells that may be the source of tumours. Gastroenteropancreatic endocrine (GEP) tumours arising within the DES secrete a variety of peptides and amines that are found in the circulation and are responsible for the syndromes associated with these tumours. In this review, the most common tumours of the GEP tract are outlined and the circulating products of these tumours identified. Where differential diagnosis is difficult these points are addressed. The peptides most commonly secreted by GEP neuroendocrine tumours are identified and described and their biological activities are discussed. Current methods available for measurement of these peptides are described. Attention is drawn towards molecular specificity where appropriate, as many pancreatic and gut peptides fall within families which show considerable homology, such as the tachykinin family or the glucagon family. Other peptides such as gastrin circulate in multiple molecular forms. This homology and diversity may cause difficulty in the interpretation of peptide measurements in the clinical situation if assays are not specific.
ACCESSION #
42525049

 

Related Articles

  • Metastatic gastrinoma to the liver 20 years after primary resection. Okuzawa, Atsushi; Kobayashi, Shigeru; Sakamoto, Kazuhiro; Uchida, Yousuke; Suzuki, Yoshimasa; Ono, Ken; Seki, Eiichirou; Tomiki, Yuuichi; Iwanuma, Yoshimi; Hayashida, Yasuo; Kamano, Toshiki; Tsurumaru, Masahiko // Journal of Gastroenterology;2000, Vol. 35 Issue 9, p717 

    Abstract: Gastrinoma is a rare endocrine tumor that is frequently associated with liver metastasis. The liver metastasis is usually seen simultaneously or soon after a primary operation. A 47-year-old woman who had had a total gastrectomy 20 years earlier developed liver metastasis. An interval...

  • TUMORI ENDOCRINE GASTROENTEROPANCREATICE. STUDII MORFOPATOLOGICE ÅžI IMUNOHISTOCHIMICE. LENCU, CODRUŢA; ŞERBAN, ALEXANDRU; ZAHARIE, TEODOR; DOMŞA, IACOB; ZOLOG, ADRIANA; LENCU, MONICA // Clujul Medical;Sep2011 Supplement, p203 

    Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare neoplasms that develop from the neuroendocrine cells of the gastroenteropancreatic tract (at least 15 types of cells), characterized by a certain (neuroendocrine) phenotype. They are capable of producing different hormones that can...

  • Familial syndromes associated with neuroendocrine tumours. Gut, Paweł; Komarowska, Hanna; Czarnywojtek, Agata; Waligórska-Stachura, Joanna; Baczyk, Maciej; Ziemnicka, Katarzyna; Fischbach, Jakub; Wrotkowska, Elzbieta; Ruchala, Marek // Contemporary Oncology / Wspolczesna Onkologia;2015, Vol. 19 Issue 3, p176 

    Neuroendocrine tumours may be associated with familial syndromes. At least eight inherited syndromes predisposing to endocrine neoplasia have been identified. Two of these are considered to be major factors predisposing to benign and malignant endocrine tumours, designated multiple endocrine...

  • Vasoactive Intestinal Peptide-Receptor Imaging for the Localization of Intestinal Adenocarcinomas and Endocrine Tumors. Virgolini, Irene; Raderer, Markus; Kurtaran, Amir; Angelberger, Peter; Banyai, Susanne; Yang, Qiong; Li, Shuren; Banyai, Martin; Pidlich, Johann; Niederle, Bruno; Scheithauer, Werner // New England Journal of Medicine;10/27/94, Vol. 331 Issue 17, p1116 

    Background: Intestinal adenocarcinomas and various endocrine tumors express large numbers of high-affinity receptors for vasoactive intestinal peptide (VIP). We have evaluated the usefulness of scanning with VIP labeled with iodine-123 for tumor localization in patients with gastrointestinal...

  • Management of Advanced Small Intestinal Neuroendocrine Tumors (Midgut Tumors). Ö berg, Kjell // European Journal of Clinical & Medical Oncology;2011, Vol. 3 Issue 1, p64 

    Small intestinal neuroendocrine tumors (carcinoids) are the most common neuroendocrine tumor (NET) within the gastrointestinal tract (15-20%). The incidence and prevalence is steadily increasing during the last decade and the estimated incidence is now about 2.5/100 000/year. The majority of the...

  • Criteria for the glucagon provocative test in the diagnosis of gastrinoma. Shibata, Chikashi; Kakyo, Masayuki; Kinouchi, Makoto; Tanaka, Naoki; Miura, Koh; Naitoh, Takeshi; Ogawa, Hitoshi; Motoi, Fuyuhiko; Egawa, Shinichi; Ueno, Tatsuya; Naito, Hiroo; Unno, Michiaki // Surgery Today;Nov2013, Vol. 43 Issue 11, p1281 

    Introduction: The glucagon provocative test is useful for the diagnosis of gastrinoma. The aim of this study was to determine the criteria for the glucagon provocative test. Methods: This study reviewed 8 patients that underwent the glucagon provocative test preoperatively and in whom the...

  • Neuroendocrine Neoplasms of the Gastrointestinal Tract.  // Deutsches Aerzteblatt International;5/6/2011, Vol. 108 Issue 18, following p312 

    A bibliography on the subject of neuroendocrine neoplasms of the gastrointestinal tract is presented which the articles "Cardiac manifestations in mid-gut carcinoid disease," by Jacobsen M. B. and colleagues, "Molecular imaging in neuroendocrine tumors: Molecular uptake mechanisms and clinical...

  • Screening of a large panel of gastrointestinal peptide plasma levels is not adapted for the evaluation of digestive damage following irradiation. Dublineau, I.; Dudoignon, N.; Monti, P.; Combes, O.; Wysocki, J.; Grison, S.; Baudelin, C.; Griffiths, N. M.; Scanff, P. // Canadian Journal of Physiology & Pharmacology;Feb2004, Vol. 82 Issue 2, p103 

    The aim of this study was to assess the potential of gastrointestinal peptide plasma levels as biomarkers of radiation-induced digestive tract damage. To this end, plasma levels of substance P, GRP, motilin, PYY, somatostatin-28, gastrin, and neurotensin were followed for up to 5 days in pigs...

  • Ectopic Pheochromocytoma: Does the Rule of Tens Apply? Madani, R.; Al-Hashmi, M.; Bliss, R.; Lennard, T.W.J. // World Journal of Surgery;Apr2007, Vol. 31 Issue 4, p849 

    The rule of “tens” is often stated to reflect the distribution and histology of pheochromocytomas, with 10% being bilateral, 10%; ectopic in origin, and 10%; malignant. The objective of this study was to review the ectopic pheochromocytomas in a tertiary endocrine center and to...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics