TITLE

Association of IL-10 and IL-10R� gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor

AUTHOR(S)
Sivula, Jyrki; Turpeinen, Hannu; Volin, Liisa; Partanen, Jukka
PUB. DATE
January 2009
SOURCE
BMC Immunology;2009, Vol. 10, Special section p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Extensive allelic matching in the human leukocyte antigen (HLA) genes is regarded as a prerequisite for good clinical success of allogeneic haematopoietic stem cell transplantation (HSCT). Also other genetic factors can be assumed to play a role in preventing and controlling the complications associated with allogeneic HSCT, in particular graft-versus-host disease (GvHD). Interleukin-10 (IL-10) and its receptor (IL-10R), key regulators of the immune response, are among these candidates. We studied the association of IL-10 and IL-10R� gene polymorphisms with the occurrence of GvHD in 309 HLA-identical sibling donor and recipient pairs. Results: The difference in genotypic IL-10 production between patient and donor in combination with patient IL-10R� A/A genotype predisposed strongly to acute GvHD (OR = 7.15, p = 0.000023). On the other hand, a combination of same genotypic IL-10 production with patient IL-10R� A/A genotype protected from chronic GvHD (OR = 0.407, p = 0.0097). Conclusion: Our results suggest that IL-10 and IL-10R� genes have a synergistic effect on the risk of GvHD.
ACCESSION #
42515830

Tags: LEUCOCYTES;  ANTIGENS;  GENES;  HEMATOPOIETIC stem cells;  INTERLEUKIN-10

 

Related Articles

  • Physiological and Non-Redundant Functions of PKC Isotypes in T Lymphocytes. Thuille, Nikolaus; Gruber, Thomas; Pfeifhofer, Christa; Hermann-Kleiter, Natascha; Lutz-Nicoladoni, Christina; Letschka, Thomas; Kollmann, Veronika; Leitges, Michael; Baier, Gottfried // Current Immunology Reviews;2006, Vol. 2 Issue 2, p143 

    This review is about the physiological and non-redundant functions of the PKC gene products in hematopoietic cells, particularly T cells. In spite of the large amount of information on PKC functions in various cell types and tissues, the characterization of the isotype selective functions of the...

  • Role of the CC Chemokine receptor 9/TECK interaction in apoptosis. Youn, B.-S.; Yu, K.-Y.; Oh, J.; Lee, J.; Lee, T.-H.; Broxmeyer, H. E. // Apoptosis;Jun2002, Vol. 7 Issue 3, p271 

    Chemokine receptors are members of the G protein coupled receptor (GPCR) supergene family whose expression is highly restricted to hematopoietic cells. Although the primary role of chemokine and chemokine receptor interaction is believed to be regulation of chemotaxis of leukocytes, subsequent...

  • Essential role for ALCAM gene silencing in megakaryocytic differentiation of K562 cells. Tan, Fang; Ghosh, Samit; Mbeunkui, Flaubert; Thomas, Robert; Weiner, Joshua A.; Ofori-Acquah, Solomon F. // BMC Molecular Biology;2010, Vol. 11, p91 

    Background: Activated leukocyte cell adhesion molecule (ALCAM/CD166) is expressed by hematopoietic stem cells. However, its role in hematopoietic differentiation has not previously been defined. Results: In this study, we show that ALCAM expression is silenced in erythromegakaryocytic progenitor...

  • Itga2b Regulation at the Onset of Definitive Hematopoiesis and Commitment to Differentiation. Dumon, Stephanie; Walton, David S.; Volpe, Giacomo; Wilson, Nicola; Dassé, Emilie; Del Pozzo, Walter; Landry, Josette-Renee; Turner, Bryan; O'Neill, Laura P.; Göttgens, Berthold; Frampton, Jon; Bunting, Kevin D. // PLoS ONE;Aug2012, Vol. 7 Issue 8, Special section p1 

    Product of the Itga2b gene, CD41 contributes to hematopoietic stem cell (HSC) and megakaryocyte/platelet functions. CD41 expression marks the onset of definitive hematopoiesis in the embryo where it participates in regulating the numbers of multipotential progenitors. Key to platelet...

  • CD34+ or CD34-: which is the more primitive? Engelhardt, M.; Lubbert, M.; Guo, Y. // Leukemia (08876924);Sep2002, Vol. 16 Issue 9, p1603 

    Remarkable progress has been achieved in the characterization and isolation of primitive hematopoietic stem cells (HSC). HSC represent a very small subset of hematopoietic cells and provide self-renewal, possess differentiation capacity and allow a constant supply of the entire hematopoietic...

  • A role for Wnt signalling in self-renewal of haematopoietic stem cells. Reya, Tannishtha; Duncan, Andrew W.; Ailles, Laurie; Domen, Jos; Scherer, David C.; Willert, Karl; Hintz, Lindsay; Nusse, Roel; Weissman, Irving L. // Nature;5/22/2003, Vol. 423 Issue 6938, p409 

    Haematopoietic stem cells (HSCs) have the ability to renew themselves and to give rise to all lineages of the blood; however, the signals that regulate HSC self-renewal remain unclear. Here we show that the Wnt signalling pathway has an important role in this process. Overexpression of activated...

  • Rapid, scalable and highly automated HLA genotyping using next-generation sequencing: a transition from research to diagnostics. Danzer, Martin; Niklas, Norbert; Stabentheiner, Stephanie; Hofer, Katja; Pröll, Johannes; Stückler, Christina; Raml, Edeltraud; Polin, Helene; Gabriel, Christian // BMC Genomics;2013, Vol. 14 Issue 1, p1 

    Background: Human leukocyte antigen matching at allelic resolution is proven clinically significant in hematopoietic stem cell transplantation, lowering the risk of graft-versus-host disease and mortality. However, due to the ever growing HLA allele database, tissue typing laboratories face...

  • CD38 expression by hematopoietic stem cells of newborn and juvenile mice. Higuchi, Y; Zeng, H; Ogawa, M // Leukemia (08876924);Jan2003, Vol. 17 Issue 1, p171 

    While investigators in a number of laboratories have documented that the hematopoietic stem cells (HSCs) of fetal and adult mice are CD38[SUP+], no information is available about CD38 expression by HSCs of newborn and juvenile mice. We used a murine transplantation model to examine HSC CD38...

  • Fish and Chips: A Fast Track to Understanding Blood Development. Eckfeldt, C. E.; Mendenhall, E. M.; Flynn, C. M.; Wang, T. F.; Pickart, M. A. // PLoS Biology;Aug2005, Vol. 3 Issue 8, p1338 

    Presents an abstract of the article "Functional Analysis of Human Hematopoietic Stem Cell Gene Expression Using Zebrafish," by C. E. Eckfeldt, E. M. Mendenhall and T. F. Wang, published in the August 15, 2005 issue of "PLoS Biology."

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics