TITLE

Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses' Health Study II

AUTHOR(S)
Koenen, Karestan C.; DeVivo, Immaculata; Rich-Edwards, Janet; Smoller, Jordan W.; Wright, Rosalind J.; Purcell, Shaun M.
PUB. DATE
January 2009
SOURCE
BMC Psychiatry;2009, Vol. 9, Special section p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: One in nine American women will meet criteria for the diagnosis of posttraumatic stress disorder (PTSD) in their lifetime. Although twin studies suggest genetic influences account for substantial variance in PTSD risk, little progress has been made in identifying variants in specific genes that influence liability to this common, debilitating disorder. Methods and design: We are using the unique resource of the Nurses Health Study II, a prospective epidemiologic cohort of 68,518 women, to conduct what promises to be the largest candidate gene association study of PTSD to date. The entire cohort will be screened for trauma exposure and PTSD; 3,000 women will be selected for PTSD diagnostic interviews based on the screening data. Our nested case-control study will genotype1000 women who developed PTSD following a history of trauma exposure; 1000 controls will be selected from women who experienced similar traumas but did not develop PTSD. The primary aim of this study is to detect genetic variants that predict the development of PTSD following trauma. We posit inherited vulnerability to PTSD is mediated by genetic variation in three specific neurobiological systems whose alterations are implicated in PTSD etiology: the hypothalamic-pituitary-adrenal axis, the locus coeruleus/ noradrenergic system, and the limbic-frontal neuro-circuitry of fear. The secondary, exploratory aim of this study is to dissect genetic influences on PTSD in the broader genetic and environmental context for the candidate genes that show significant association with PTSD in detection analyses. This will involve: conducting conditional tests to identify the causal genetic variant among multiple correlated signals; testing whether the effect of PTSD genetic risk variants is moderated by age of first trauma, trauma type, and trauma severity; and exploring gene-gene interactions using a novel gene-based statistical approach. Discussion: Identification of liability genes for PTSD would represent a major advance in understanding the pathophysiology of the disorder. Such understanding could advance the development of new pharmacological agents for PTSD treatment and prevention. Moreover, the addition of PTSD assessment data will make the NHSII cohort an unparalleled resource for future genetic studies of PTSD as well as provide the unique opportunity for the prospective examination of PTSD-disease associations.
ACCESSION #
42408656

 

Related Articles

  • Gene-environment interaction in posttraumatic stress disorder. Koenen, Karestan C.; Nugent, Nicole R.; Amstadter, Ananda B. // European Archives of Psychiatry & Clinical Neuroscience;Mar2008, Vol. 258 Issue 2, p82 

    The purpose of this article is to encourage research investigating the role of measured gene-environment interaction (G × E) in the etiology of posttraumatic stress disorder (PTSD). PTSD is uniquely suited to the study of G × E as the diagnosis requires exposure to a...

  • Biological Factors Associated With Susceptibility to Posttraumatic Stress Disorder. Yehuda, Rachel // Canadian Journal of Psychiatry;Feb1999, Vol. 44 Issue 1, p34 

    Presents information on a study which examines the biological factors that are attributed to posttraumatic stress disorder (PTSD). Discussion on the nature of PTSD; Several categories of putative risk factors for PSTD; Function of cortisol in treating PSTD.

  • Beyond our experience. Greenberg, Samuel I. // Cortlandt Forum;01/25/97, Vol. 10 Issue 1, p60 

    Details the experience of a psychiatrist with a woman who was diagnosed to have post-traumatic stress disorder. Woman as one of the survivors of the Jewish Holocaust; Case as the doctor's first civilian patient of the disorder.

  • Clinical Characteristics and Efficacious Treatment of Posttraumatic Stress Disorder in Children and Adolescents. Brown, Elissa J. // Pediatric Annals;Feb2005, Vol. 34 Issue 2, p138 

    The article discusses the clinical features and efficacious treatment of postraumatic stress disorder (PTSD) in children and adolescents. Among the possible origins of PTSD include war and terrorism. The American Academy of Child and Adolescent Psychiatry has developed guidelines for the...

  • Psychiatric Disorders and Treatment in Low-Income Pregnant Women. Cook, Cynthia A. Loveland; Flick, Louise H.; Homan, Sharon M.; Campbell, Claudia; McSweeney, Maryellen; Gallagher, Mary Elizabeth // Journal of Women's Health (15409996);Jul2010, Vol. 19 Issue 7, p1251 

    Aims: This study estimated the prevalence of twenty-two 12-month and lifetime psychiatric disorders in a sample of 744 low-income pregnant women and the frequency that women with psychiatric disorders received treatment. Method: To identify psychiatric disorders, the Diagnostic Interview...

  • Response categories and anger measurement: do fewer categories result in poorer measurement? Hawthorne, Graeme; Mouthaan, Joanne; Forbes, David; Novaco, Raymond W. // Social Psychiatry & Psychiatric Epidemiology;Feb2006, Vol. 41 Issue 2, p164 

    Background Anger is a key long-term outcome from trauma exposure, regardless of trauma type, and it is implicated as a moderator of response to treatment. It therefore seems important that anger is assessed in both epidemiological studies of trauma sequelae and in intervention evaluation...

  • Individual Differences in Posttraumatic Distress: Problems With the DSM-IV Model. Laura Bowman,, Marilyn // Canadian Journal of Psychiatry;Feb1999, Vol. 44 Issue 1, p21 

    Presents information on a study which evaluated the evidence concerning the role of threatening life events in accounting for clinically significant posttraumatic stress responses. Examination on the Diagnostic and Statistical Manual of Mental Disorders model; Discussion on factors which must be...

  • Critical perspectives on research on post-traumatic stress disorder and implications for the South African context. Edwards, David // Journal of Psychology in Africa;2005, Vol. 15 Issue 2, p117 

    This article introduces a special issue of the Journal of Psychology in Africa on post-traumatic stress disorder (PTSD) in Africa and particularly in South Africa and examines the critical debate that has surrounded PTSD research. It begins with an examination of the meaning of the term trauma,...

  • Post-traumatic stress disorder as a public health concern in South Africa. Edwards, David // Journal of Psychology in Africa;2005, Vol. 15 Issue 2, p125 

    This article briefly surveys the extent to which traumatic events are a feature of life all over Africa and provides a comprehensive review of research that documents the pervasiveness of traumatic events in South Africa and the prevalence of PTSD symptoms. The material reviewed includes...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics