TITLE

Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA

AUTHOR(S)
Siddiqa, Aisha; Sims-Mourtada, Jennifer C.; Guzman-Rojas, Liliana; Rangel, Roberto; Guret, Christiane; Madrid-Marina, Vicente; Yan Sun; Martinez-Valdez, Hector
PUB. DATE
March 2001
SOURCE
Nature;3/15/2001, Vol. 410 Issue 6826, p383
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Describes AKNA, a human AT-hook protein that directly binds the A/T-rich regulatory elements of the promoters of CD40 and CD40 ligand (CD40L) and coordinately regulates their expression. How it contains multiple PEST protein-cleavage motifs; Expression of AKNA by B and T lymphocytes, natural killer cells and dendritic cells, and in B-lymphocyte differentiation; Conclusion that an AT-hook molecule can regulate the expression of a key receptor and its ligand, and point towards a molecular mechanism that explains homotypic cell interactions.
ACCESSION #
4223522

 

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