Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA

Siddiqa, Aisha; Sims-Mourtada, Jennifer C.; Guzman-Rojas, Liliana; Rangel, Roberto; Guret, Christiane; Madrid-Marina, Vicente; Yan Sun; Martinez-Valdez, Hector
March 2001
Nature;3/15/2001, Vol. 410 Issue 6826, p383
Academic Journal
Describes AKNA, a human AT-hook protein that directly binds the A/T-rich regulatory elements of the promoters of CD40 and CD40 ligand (CD40L) and coordinately regulates their expression. How it contains multiple PEST protein-cleavage motifs; Expression of AKNA by B and T lymphocytes, natural killer cells and dendritic cells, and in B-lymphocyte differentiation; Conclusion that an AT-hook molecule can regulate the expression of a key receptor and its ligand, and point towards a molecular mechanism that explains homotypic cell interactions.


Related Articles

  • Regulation of cytokine signaling pathways by PIAS proteins. Shuai, Ke // Cell Research;Feb2006, Vol. 16 Issue 2, p196 

    Cytokines activate multiple signal transduction pathways to regulate gene expression. STATs and NF-kB are two important families of transcription factors activated by cytokines. Abnormal regulation of STAT and NF-kB activities has been associated with human diseases. The protein inhibitor of...

  • Global and gene-specific analyses show distinct roles for Myod and Myog at a common set of promoters. Yi Cao; Kumar, Roshan M.; Penn, Bennett H.; Berkes, Charlotte A.; Kooperberg, Charles; Boyer, Laurie A.; Young, Richard A.; Tapscott, Stephen J. // EMBO Journal;2/8/2006, Vol. 25 Issue 3, p502 

    We used a combination of genome-wide and promoter-specific DNA binding and expression analyses to assess the functional roles of Myod and Myog in regulating the program of skeletal muscle gene expression. Our findings indicate that Myod and Myog have distinct regulatory roles at a similar set of...

  • In-Silico Identification of Putative p53 Transcription Factor DNA-Binding Sites and Detection of hnRNP Genes Regulated by p53. Dutta, Avirup; Chatterjee, Raghunath; Roychoudhury, Paromita; Roy, Patanjal; Chaudhuri, Keya // IUP Journal of Biotechnology;Jun2010, Vol. 4 Issue 2, p7 

    An evolutionary ancient transcription factor p53 coordinates diverse cellular responses to stress and damage and plays an emerging role in various physiological processes by regulating the expression of a number of genes of diverse families and pathways. The p53 DNA-binding motif consists of a...

  • TOBFAC: the database of tobacco transcription factors. Rushton, Paul J.; Bokowiec, Marta T.; Laudeman, Thomas W.; Brannock, Jennifer F.; Xianfeng Chen; Timko, Michael P. // BMC Bioinformatics;2008, Vol. 9, Special section p1 

    Background: Regulation of gene expression at the level of transcription is a major control point in many biological processes. Transcription factors (TFs) can activate and/or repress the transcriptional rate of target genes and vascular plant genomes devote approximately 7% of their coding...

  • Rbfox proteins regulate alternative mRNA splicing through evolutionarily conserved RNA bridges. Lovci, Michael T; Ghanem, Dana; Marr, Henry; Arnold, Justin; Gee, Sherry; Parra, Marilyn; Liang, Tiffany Y; Stark, Thomas J; Gehman, Lauren T; Hoon, Shawn; Massirer, Katlin B; Pratt, Gabriel A; Black, Douglas L; Gray, Joe W; Conboy, John G; Yeo, Gene W // Nature Structural & Molecular Biology;Dec2013, Vol. 20 Issue 12, p1434 

    Alternative splicing (AS) enables programmed diversity of gene expression across tissues and development. We show here that binding in distal intronic regions (>500 nucleotides (nt) from any exon) by Rbfox splicing factors important in development is extensive and is an active mode of splicing...

  • Nucleosome destabilization in the epigenetic regulation of gene expression. Henikoff, Steven // Nature Reviews Genetics;Jan2008, Vol. 9 Issue 1, p15 

    Assembly, mobilization and disassembly of nucleosomes can influence the regulation of gene expression and other processes that act on eukaryotic DNA. Distinct nucleosome-assembly pathways deposit dimeric subunits behind the replication fork or at sites of active processes that mobilize...

  • Robust, synergistic regulation of human gene expression using TALE activators. Maeder, Morgan L; Linder, Samantha J; Reyon, Deepak; Angstman, James F; Fu, Yanfang; Sander, Jeffry D; Joung, J Keith // Nature Methods;Mar2013, Vol. 10 Issue 3, p243 

    Artificial activators designed using transcription activator-like effector (TALE) technology have broad utility, but previous studies suggest that these monomeric proteins often exhibit low activities. Here we demonstrate that TALE activators can robustly function individually or in synergistic...

  • Orphan nuclear receptors: current perspectives. Ranhotra, Harmit S. // Journal of Receptor, Ligand & Channel Research;2013, Vol. 6, p15 

    Living organisms require a host of regulatory circuits in order to survive optimally in a given environment. Gene regulation is one of the most important mechanisms for achieving normal cellular activities and overall homeostasis. The orphan nuclear receptors (ONRs) belonging to the nuclear...

  • Identification of DNA-binding protein target sequences by physical effective energy functions: free energy analysis of lambda repressor-DNA complexes. Moroni, Elisabetta; Caselle, Michele; Fogolari, Federico // BMC Structural Biology;2007, Vol. 7, p61 

    Background: Specific binding of proteins to DNA is one of the most common ways gene expression is controlled. Although general rules for the DNA-protein recognition can be derived, the ambiguous and complex nature of this mechanism precludes a simple recognition code, therefore the prediction of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics