TITLE

Quantitative Analysis of Carisoprodol and Meprobamate in Whole Blood Using Benzylcarbamate and Deuterated Meprobamate as Internal Standards

AUTHOR(S)
Downey, Delisa; Simons, Kelsie; Ota, Kenji; Kerrigan, Sarah
PUB. DATE
June 2009
SOURCE
Journal of Analytical Toxicology;Jun2009, Vol. 33 Issue 5, p278
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study which examines the limit of linearity, limit of detection (LOD), and limit of quantification (LOQ) of carisoprodol and meprobamate in whole blood. It notes that solid-phase extraction and gas chromatography-mass spectrometry (GC-MS) with benzylcarbamate and meprobamate-d7 as internal standard were used to determine the drugs in whole blood. Results show that calibrations for both drugs remained linear to 100 mg/L when meprobamate-d7 was used as the internal standard while their LOQs, regardless of internal standard, was 0.4 mg/L. Furthermore, results proved that either benzylcarbamate or meprobamate-d7 can be used as internal standard for quantitative analysis of the drugs from whole blood.
ACCESSION #
42220894

 

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