TITLE

Atorvastatin reduces the expression of aldo-keto reductases in HUVEC and PTEC. Anew approach to influence the polyol pathway

AUTHOR(S)
Ruf, Tobias F.; Quintes, Susanne; Sternik, Paula; Gottmann, Uwe
PUB. DATE
June 2009
SOURCE
Clinical & Investigative Medicine;Jun2009, Vol. 32 Issue 3, pE219
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Purpose: Increased flux of glucose via the polyol pathway, oxidative stress and ischaemia lead to the upregulation of the aldose reductase (AR), the key enzyme of the polyol pathway. This adversely affects the organism and can in part be reduced by inhibition of the enzyme. Methods: In this study, we examined the effect of the HMG-CoA-reductase inhibitor atorvastatin on the expression of aldose reductase (AR, AKR1B1), aldehyde reductase (AldR, AKR1A1) and small intestine reductase (SIR, AKR1B10) in human umbilical vein endothelial cells (HUVEC) and human proximal tubular epithelial cells (PTEC) by RT-PCR. Results: In HUVEC, atorvastatin reduces the expression of aldehyde reductase and aldose reductase compared with control medium (-20% and -12% respectively, P<0.05), while small intestine reductase is not expressed. In PTEC no regulation of aldehyde reductase and aldose reductase by atorvastatin could be measured, while the expression of small intestine reductase was reduced by 37% compared with control medium (P<0.05). The reduction observed was not abolished by the addition of mevalonic acid. Conclusion: The reduction of members of the aldo-ketoreductase family by atorvastatin is a novel way to influence the polyol pathway and a new pleiotropic effect of atorvastatin.
ACCESSION #
42093369

 

Related Articles

  • CT examination of mesenteric vessels and small bowel. Horton, Karen M. // Applied Radiology;Dec2004 Supplement, Vol. 33, p45 

    Focuses on computed tomography examination of mesenteric vessels and small bowel. Information on acute mesenteric ischemia; Facts about chronic mesenteric ischemia; Explanation on the four types of tumors on small-bowel neoplasms.

  • Differential Diagnostic Aspects Are Lacking. Lehmann, Karla // Deutsches Aerzteblatt International;10/18/2012, Vol. 109 Issue 42, p709 

    A letter to the editor is presented in response to an article on the diagnosis and treatment of acute mesenteric ischemia.

  • Acute Stroke with Hyperdense Middle Cerebral Artery Sign Benefits from IV rtPA. Tartaglia, M. C.; Di Legge, S.; Saposnik, G.; Jain, V.; Chan, R.; Bussière, M.; Hachinski, V.; Frank, C.; Hesser, K.; Pelz, D. // Canadian Journal of Neurological Sciences;Nov2008, Vol. 35 Issue 5, p583 

    Objectives: The current management of acute ischemic stroke is intravenous (IV) recombinant tissue plasminogen activator (rtPA). The presence of a hyperdense middle cerebral artery sign (HMCAS) on pre-treatment head computed tomogram (CT) is considered a poor prognostic sign. We compared the...

  • Coingestion of cyclooxygenase inhibitors can worsen severe paracetamol poisoning by middle-sized and small arteries vasoconstriction. Schneider, Francis; Neuville, Agnès; Meziani, Ferhat; Meyer, Carole; Assemi, Parissa; Lavigne, Thierry; Castelain, Vincent; Neuville, Agnès // Intensive Care Medicine;Nov2003, Vol. 29 Issue 11, p2090 

    Objective: We report fatal cases of multifocal ischemic injuries occurring in patients awaiting liver transplantation after severe concomitant paracetamol and cyclooygenase inhibitors self-poisoning.Design and Setting: Case report in an intensive care...

  • Untitled. Minhas, Gillipsie; Anand, Akshay // Annals of Neurosciences;2015, Vol. 22 Issue 4, p249 

    Two images are presented which feature mouse retinal wholemounts showing vasculature in a retinal ischemia model.

  • An investigation of human jejunal and ileal arteries. Conley, Dylan; Hurst, Peter; Stringer, Mark // Anatomical Science International;Mar2010, Vol. 85 Issue 1, p23 

    The arrangement of jejunal and ileal arteries varies along the length of the small bowel, but the reasons for this and the functional implications are uncertain. The aims of this anatomical and histological study were to investigate quantitative differences between jejunal and ileal arteries and...

  • Octreotide in the Treatment of Bleeding Due to Angiodysplasia of the Small Intestine. Rossini, Francesco Paolo; Arrigoni, Arrigo; Pennazio, Marco // American Journal of Gastroenterology;Sep1993, Vol. 88 Issue 9, p1424 

    Three patients with a history of bleeding due to small bowel angiodysplasia (repeated melena or occult fecal blood with serious anemia) were treated for 10-40 months with octreotide, a somatostatin analog that reduces the splanchnic flow. A dose of 0.1 mg subcutaneously twice a day was followed...

  • Protein kinase C inhibition attenuates vascular ETB receptor upregulation and decreases brain damage after cerebral ischemia in rat. Henriksson, Marie; Stenman, Emelie; Vikman, Petter; Edvinsson, Lars // BMC Neuroscience;2007, Vol. 8, p1 

    Background: Protein kinase C (PKC) is known to be involved in the pathophysiology of experimental cerebral ischemia. We have previously shown that after transient middle cerebral artery occlusion, there is an upregulation of endothelin receptors in the ipsilateral middle cerebral artery. The...

  • Ischemic preconditioning and remote ischemic preconditioning have protective effect against cold ischemia-reperfusion injury of rat small intestine. Saeki, Isamu; Matsuura, Toshiharu; Hayashida, Makoto; Taguchi, Tomoaki // Pediatric Surgery International;Aug2011, Vol. 27 Issue 8, p857 

    Purpose: To investigate the protective effect of ischemic preconditioning (IPC) and remote ischemic preconditioning (RIPC) against cold ischemia-reperfusion injury (IRI) associated with small bowel transplantation (SBT).Methods: Male Lewis rats weighing 200-300 g were...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics