TITLE

Hemin-induced suicidal erythrocyte death

AUTHOR(S)
Gatidis, Sergios; Föller, Michael; Lang, Florian
PUB. DATE
August 2009
SOURCE
Annals of Hematology;Aug2009, Vol. 88 Issue 8, p721
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Several diseases, such as malaria, sickle cell disease, and ischemia/reperfusion may cause excessive formation of hemin, which may in turn trigger hemolysis. A variety of drugs and diseases leading to hemolysis triggers suicidal erythrocyte death or eryptosis, i.e., cell membrane scrambling and cell shrinkage. Eryptosis is elicited by increased cytosolic Ca2+ activity and by ceramide. The present study explored whether hemin stimulates eryptosis. Cell membrane scrambling was estimated from annexin V-binding to phosphatidylserine exposed at the cell surface, cell shrinkage from forward scatter in fluorescence-activated cell sorter analysis, cytosolic Ca2+ activity from Fluo3 fluorescence and ceramide formation from fluorescence-labeled antibody binding. Exposure to hemin (1–10 μM) within 48 h significantly increased annexin V-binding, decreased forward scatter, increased cytosolic Ca2+ activity, and stimulated ceramide formation. In conclusion, hemin stimulates suicidal cell death, which may in turn contribute to the clearance of circulating erythrocytes and thus to anemia.
ACCESSION #
41677095

 

Related Articles

  • Triggering of Eryptosis, the Suicidal Erythrocyte Death, by Perifosine. Egler, Jasmin; Lang, Florian // Cellular Physiology & Biochemistry (Karger AG);Jun2017, Vol. 42 Issue 1, p2534 

    Background/Aims: The alkylphospholipid perifosine is used for the treatment of malignancy. The substance is effective by triggering suicidal tumor cell death or apoptosis. Side effects of perifosine include anemia. At least in theory, perifosine-induced anemia could result from stimulation of...

  • hemolysin.  // Taber's Cyclopedic Medical Dictionary;2005, p967 

    A definition of the medical term "hemolysin" is presented. Hemolysin, which is synonymous to hemotoxin, refers to a toxic agent or condition that destroys red blood cells. The definition is from the "Taber's Cyclopedic Medical Dictionary," published by F.A. Davis Co. The pronunciation of the...

  • Intravascular lymphoma associated with hemophagocytic syndrome: a rare but aggressive clinical entity. Bhagwati, Niyati S.; Oiseth, Stanley J.; Abebe, Lool S.; Wiernik, Peter H. // Annals of Hematology;Apr2004, Vol. 83 Issue 4, p247 

    We report a 55-year-old male with a diagnosis of intravascular lymphoma and hemophagocytosis. He initially presented with hemolytic anemia and splenomegaly and was successfully treated with oral steroids. His clinical course was later complicated by fever, cytopenias, hypoalbuminemia,...

  • Intravascular lymphoma associated with hemophagocytic syndrome: a rare but aggressive clinical entity. Bhagwati, Niyati S.; Oiseth, Stanley J.; Abebe, Lool S.; Wiernik, Peter H. // Annals of Hematology;Apr2004, Vol. 83 Issue 4, p247 

    We report a 55-year-old male with a diagnosis of intravascular lymphoma and hemophagocytosis. He initially presented with hemolytic anemia and splenomegaly and was successfully treated with oral steroids. His clinical course was later complicated by fever, cytopenias, hypoalbuminemia,...

  • Benzidine-positive Pigments in Serum of Patients with Sickle Cell Anemia During Painful Crises. Iuchi, Iwao; Diggs, L.W.; Upshaw Jr., J.D. // Annals of Internal Medicine;Jun64, Vol. 60 Issue 6, p1022 

    Summarizes the reported values of Benzidine-positive pigments in the serum of patients with sickle cell anemia during painful crises. Evidence that support the claim that hemolysis is not a major component in the recurrent episodes of pain and fever; Characteristics of painful sickle cell crises.

  • Zieve's syndrome presenting with coagulopathy, skin and subcutaneous haemorrhage. Kondrackienė, Jūratė; Beinaravičienė, Inga; Gelman, Sigita; Kupčinskas, Limas // Acta Medica Lituanica;2012, Vol. 19 Issue 4, p403 

    Zieve syndrome is characterized by hepatic dysfunction, jaundice, hyperlipidaemia, and reversible hemolytic anaemia after alcohol abuse. We report a rare case of this syndrome presenting with coagulopathy and subcutaneous haemorrhage. Laboratory tests showed macrocytic anaemia,...

  • First North American case of Hemoglobin Shepherds Bush (β 74[E18] Gly → Asp) in a central Pennsylvania family. Paradise, Scott L.; Estep, Lauren; Olson, Jordan; Donaldson, Keri // BMC Clinical Pathology; 

    Background Hemoglobin Shepherds Bush (Human Genome Variation Society name: HBB:c.224G > A) is an unstable hemoglobin variant resulting from a β 74 GGC to GAC mutation (Gly to Asp) that manifests clinically as hemolytic anemia or gall bladder disease due to chronic subclinical hemolysis. Case...

  • Isoimmune haemolysis in pathogenesis of anaemia after cardiac surgery. Boughton, B.J.; Galbraith, P.R. // British Medical Journal;11/22/1975, Vol. 4 Issue 5994, p430 

    Describes the isoimmune hemolysis in pathogenesis of anemia after cardiac surgery. Development of antiglobulin-positive hemolytic anemia on patient after receiving multiple transfusions; Fragmentation of erythrocytes; Malfunction of prosthetic heart valves.

  • A case of haemolytic anaemia caused by cold agglutinins. Gupta, Sunita; Jain, Arun; Balani, Sharda; Verma, Rashmi; Priyadarshini, Jyoti; Shrivastava, Manisha; Dabadghao, Sunil; Jain, Aruna // Asian Journal of Transfusion Science;Jan-Jun2008, Vol. 2 Issue 1, p29 

    Background: Cold agglutinins are IgM autoantibodies, which are often detected incidentally. They are rarely pathogenic. Natural cold autoantibodies occur in titers less than 1:64 measured at 4°C and have no activity at temperature higher than 22°C, However pathogenic cold agglutinins...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics