Monocyte-Derived Dendritic Cells from HIV Type 1—Infected Individuals Show Reduced Ability to Stimulate T Cells and Have Altered Production of Interleukin (IL)—12 and IL-10

Buisson, Sandrine; Benlahrech, Adel; Gazzard, Brian; Gotch, Frances; Kelleher, Peter; Patterson, Steven
June 2009
Journal of Infectious Diseases;6/15/2009, Vol. 199 Issue 12, p1862
Academic Journal
Monocyte-derived dendritic cells (MDDCs) have been used in therapeutic vaccination for cancer.Asmall number of studies have employed a similar approach to vaccinate human immunodeficiency virus (HIV)-infected individuals. We have thus analyzed the functional properties of MDDCs generated from HIV-infected individuals who either are receiving highly active antiretroviral therapy or are therapy naive. There was no difference in the MDDC phenotype or efficiency of MDDC generation between HIV-infected individuals and healthy control subjects. Despite this, the MDDCs derived from both groups of infected individuals were severely impaired in their ability to stimulate the proliferation of allogeneic T cells. Furthermore, production of interferon-γ was reduced in Tcells stimulated by MDDCs. These functional changesmaybe at least partly explained by reduced interleukin-12 and increased interleukin-10 secretion on stimulation with lipopolysaccharide and CD40 ligand. Our findings suggest that MDDCs used in therapeutic vaccination of HIV-infected individuals may show reduced potency.


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