TITLE

Effects of synovial fluid from aseptic prosthesis loosening on collagen production in osteoblasts

AUTHOR(S)
Martin Andersson; Mikael Ivarsson; Barbro Granberg; André Stark
PUB. DATE
June 2009
SOURCE
International Orthopaedics;Jun2009, Vol. 33 Issue 3, p873
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract  Synovial fluid from a loose prosthesis may act as a vehicle for factors that regulate bone turnover. The effect of such synovial fluid on osteoblasts has been studied. Synovial fluid obtained from patients who underwent revision hip arthroplasty because of aseptic prosthesis loosening was studied regarding the effect on protein synthesis, procollagen I mRNA expression, the secretion of procollagen I carboxyterminal propeptide (PICP) and osteocalcin in MG63 osteoblasts. Protein synthesis was increased and procollagen I mRNA expression was decreased by synovial fluid from patients with prosthesis loosening. Synovial fluid stimulated the total PICP in cell medium, but there was no change after correction for cell protein content in the cells. Synovial fluid in patients with prosthesis loosening has a general stimulatory effect on collagen formation and osteoblast proliferation because of a stimulatory effect on cell growth. Aseptic prosthesis loosening may be associated with an increase in bone formation.
ACCESSION #
41427075

 

Related Articles

  • Interleukin-6 in Serum and in Synovial Fluid Enhances the Differentiation between Periprosthetic Joint Infection and Aseptic Loosening. Randau, Thomas M.; Friedrich, Max J.; Wimmer, Matthias D.; Reichert, Ben; Kuberra, Dominik; Stoffel-Wagner, Birgit; Limmer, Andreas; Wirtz, Dieter C.; Gravius, Sascha // PLoS ONE;Feb2014, Vol. 9 Issue 2, p1 

    The preoperative differentiation between septic and aseptic loosening after total hip or knee arthroplasty is essential for successful therapy and relies in part on biomarkers. The objective of this study was to assess synovial and serum levels of inflammatory proteins as diagnostic tool for...

  • Hyaluronan in synovial fluid of patients with loose total hip prosthesis : Comparison with hyaluronan in patients with hip osteoarthritis and idiopathic osteonecrosis of femoral head. Yamada, Harumoto; Morita, Mitsuhiro; Henmi, Osamu; Miyauchi, Satoshi; Yoshida, Yuko; Kikuchi, Toshiyuki; Terada, Nobuki; Washimi, Osuke; Washimi, Y.; Seki, Tsuneo // Archives of Orthopaedic & Trauma Surgery;Sep2000, Vol. 120 Issue 9, p521 

    The concentration and molecular weight of hyaluronan (HA) in the synovial fluid of the hip joint were determined in 13 patients (aged 62.8 ± 9.4 years) who had undergone prior total hip arthroplasty(THA), 23 patients (aged 65.0 ± 8.2 years) with osteoarthritis of the hip joint (OA), and 13...

  • Early Migration Predicts Aseptic Loosening of Cementless Femoral Stems: A Long-term Study. Streit, Marcus; Haeussler, Daniel; Bruckner, Thomas; Proctor, Tanja; Innmann, Moritz; Merle, Christian; Gotterbarm, Tobias; Weiss, Stefan; Streit, Marcus R; Innmann, Moritz M // Clinical Orthopaedics & Related Research;Jul2016, Vol. 474 Issue 7, p1697 

    Background: Excessive early migration of cemented stems and cups after THA has been associated with poor long-term survival and allows predictable evaluation of implant performance. However, there are few data regarding the relationship between early migration and aseptic loosening...

  • METALLOSIS AND METAL-ON-METAL BEARINGS. Beaule, Paul E.; Campbell, Patricia; Amstutz, Harlan C.; Iida, Hirokazu; Kaneda, Eishi; Takada, Hideaki; Kawanabe, Kanji; Nakamura, Takashi // Journal of Bone & Joint Surgery, American Volume;May2000, Vol. 82-A Issue 5, p751 

    Presents correspondence about and metallosis and metal-onmetal bearings. Comments on the article, titled 'Metallosis due to impingement between the socket and the femoral neck in a metal-on-metal bearing total hip prosthesis. A case report,' by Iida and others; Reply of Iida and others on...

  • Short-term revision risk similar for uncemented large-head, cemented THA. Craven, Jeff // Orthopaedics Today Europe;2012, Vol. 15 Issue 2, p1 

    The article discusses a study on the relative risk of revision found among 8,059 cementless total hip arthroplasty (THA) procedures performed with large-diameter head metal-on-metal prostheses.

  • Examining femoral modularity in THA.  // Orthopedics Today;Feb2014, Vol. 34 Issue 2, p17 

    The article discusses the highlights of a "Round Table" discussion for providing insights into the pros and cons of modular femoral hip stems for both primary and revision reconstruction, wherein the participants of the discussion included orthopedic surgeons Dr. Allan E. Gross, Dr. Wayne G....

  • Frictional heating of bearing materials tested in a hip joint wear simulator. Lu, Z; McKellop, H // Proceedings of the Institution of Mechanical Engineers -- Part H;1997, Vol. 211 Issue 1, p101 

    In a hip simulator wear test using bovine serum as a lubricant, the heat generated by ball-cup friction may cause precipitation of the proteins from the lubricant. The resultant accumulation of a solid layer of precipitated protein between the ball and cup could artificially protect the bearing...

  • The frictional behaviour of explanted PCA hip prostheses. Elfick, A P; Hall, R M; Unsworth, A; Pinder, I M // Proceedings of the Institution of Mechanical Engineers -- Part H;Sep98, Vol. 212 Issue 5, p395 

    The frictional characteristic of 22 explanted and two unused PCA total hip arthoplasties were assessed using the Durham hip simulator. The friction of the explanted joints was not found to be significantly different from that of the unused joints. In contrast, explanted Charnley joints often...

  • New Approach to Hip Replacement.  // USA Today Magazine;Feb2002, Vol. 130 Issue 2681, p15 

    Describes a modified approach to hip replacement surgery. Use of cementless prosthesis that grows on the bone; Reduction of hospital stay; Use of slender portals versus large incisions; Duration of operating time.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics