Mitochondrial dysfunction resulting from loss of cytochrome c impairs radiation-induced bystander effect

Yang, G.; Wu, L.; Chen, S.; Zhu, L.; Huang, P.; Tong, L.; Zhao, Y.; Zhao, G.; Wang, J.; Mei, T.; Xu, A.; Wang, Y.
June 2009
British Journal of Cancer;6/16/2009, Vol. 100 Issue 12, p1912
Academic Journal
Cytochrome c is a pivotal protein that resides in mitochondria as component of mitochondria respiration and apoptosis initiator. Using murine cells lacking cytochrome c, we showed here that cytochrome c-deficient cells had attenuated reactive oxygen species/nitric oxide and micronuclei induction to radiation-induced bystander signals, indicating cytochrome c is essential for the bystander effect.British Journal of Cancer (2009) 100, 1912–1916; doi:10.1038/sj.bjc.6605087; published online 19 May 2009; www.bjcancer.com


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