TITLE

Bevacizumab combined with gemcitabine and capecitabine for advanced pancreatic cancer: a phase II study

AUTHOR(S)
Javle, M.; Yu, J.; Garrett, C.; Pande, A.; Kuvshinoff, B.; Litwin, A.; Phelan III, J.; Gibbs, J.; Iyer, R.
PUB. DATE
June 2009
SOURCE
British Journal of Cancer;6/16/2009, Vol. 100 Issue 12, p1842
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A total of 50 patients with advanced pancreatic cancer were enrolled in a phase II study of bevacizumab 15 mg kg−1, capecitabine 1300 mg m−2 daily for 2 weeks and gemcitabine 1000 mg m−2 weekly 2 times; cycles were repeated every 21 days. Radiological response rate was 22%; progression-free survival and over survival were 5.8 and 9.8 months respectively. Grade 3 or 4 toxicities included neutropaenia (22%), thrombocytopaenia (14%), thromboembolic events (12%), hypertension (8%) and haemorrhage (6%).British Journal of Cancer (2009) 100, 1842–1845; doi:10.1038/sj.bjc.6605099; published online 2 June 2009; www.bjcancer.com
ACCESSION #
41335418

 

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