PSA sierico e volume della zona di transizione in pazienti con IPB

December 2009
Urologia;2009 Supplement, Vol. 76 Issue S-12, pS34
Academic Journal
In the single individual it is not possible to precisely determine the contribution of the benign prostatic hyperplasia to the raising of the PSA. We have analyzed the course of the PSA in 67 patients undergoing open prostatectomy for benign prostatic hyperplasia with the goal to appraise the existing relationships between PSA and volume of the transition zone. We have considered the followings data: pre-operating PSA, post-operating PSA to 3 months from the surgery, weight of the prostatic adenoma removed. We have ascertained that the surgical intervention has determined a reduction of PSA levels of the 90%; in detail the value of PSA serum has gone down to inferior values to 2 ng/ml in the 97% of the times and to 1 ng/ml in the 88% of the cases. A meaningful correlation statistically exists between the PSA and weight of the removed adenoma (r=0.24, p <0.03), despite is not possible to show a linear relationship between the variation of the weight and the variation of the PSA such that can be express as a constant percentage among the two variable (the contribution of the volume of the adenoma to the raising of the PSA results inclusive between 0.01 and 0. 16 ng/ml/gr). For every range of PSA the volume of the TZ is not correlated to the total value of PSA, probably because a difference exists in the quantity of manufacturing epithelium of PSA in prostates of similar dimensions, and, to the moment, some method not invasive doesn't exist for determining how much epithelium is contributing to the global value of the PSA (a modern urologic dilemma).


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