TITLE

Synthesis, characterisation and chromatographic evaluation of polyether dendrimer stationary phases

AUTHOR(S)

O'Sullivan, Gerard P.; Scully, Norma M.; Prat, Jean-Marie; Glennon, Jeremy D.; Dietrich, Benjamin; Friebolin, Volker; Albert, Klaus

PUB. DATE

July 2009

SOURCE

Analytical & Bioanalytical Chemistry;Jul2009, Vol. 394 Issue 5, p1261

SOURCE TYPE

Academic Journal

DOC. TYPE

Article

ABSTRACT

Supercritical carbon dioxide has attracted attention as a potential replacement for traditional organic solvents due to its simplified workup procedures and reduced environmental impact—providing a green chemistry approach for organic solvent-free functionalisation. In addition to the environmental benefits, the enhanced diffusivity observed in supercritical solvents can often enhance reaction rates. We have applied these valuable features to the preparation of silica-bonded stationary phases and examined their potential in liquid chromatography. We report the successful preparation and characterisation of polyether silica based on Frechet dendrimers—this significantly enhances the range of stationary-phase chemistries that can be prepared in supercritical fluids. First- and second-generation polyether silicas were prepared, characterised, end-capped and evaluated for use as stationary phases for liquid chromatography. [Figure not available: see fulltext.]

ACCESSION #

41328803

 

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