Grapefruit and breast cancer in postmenopausal women: seeking the bitter truth

Brown, Simon
September 2007
Menopause International;Sep2007, Vol. 13 Issue 3, p94
Academic Journal
The article considers the correlation between grapefruit and the risk of breast cancer in postmenopausal women, based on a study published online by the "British Journal of Cancer." It is noted in the study, which is part of the Hawaii-Los Angeles Multiethnic Cohort Study, that grapefruit is a well established inhibitor of a cytochrome known as CYP3A4, which is involved in the metabolism of estrogens. Investigators hypothesized that grapefruit may increase estrogen concentrations in plasma. But the link between grapefruit and breast cancer was questioned by the charity Breast Cancer Care.


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