Update: Drug Susceptibility of Swine-Origin Influenza A (H1N1) Viruses, April 2009

Gubareva, L.; Okomo-Adhiambo, M.; Deyde, V.; Fry, A. M.; Sheu, T. G.; Garden, R; Smith, C.; Barnes, J.; Myrick, A.; Hillman, M.; Shaw, M.; Bridges, C.; Klimov, A.; Cox, N.
May 2009
MMWR: Morbidity & Mortality Weekly Report;5/1/2009, Vol. 58 Issue 16, p433
The article reports the susceptibility and resistance of swine-origin influenza A (H1N1) virus to certain drugs. As of April 2009, 13 viruses are resistant to amantadine and rimantidine (adamantane class) but are susceptible to oseltamivir and zanamivir. Oseltamivir (Tamiflu) is orally bioavailable while zanamivir (Relenza) must be inhaled. Another drug which is undergoing clinical trials is peramivir which is formulated for intravenous administration.


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