TITLE

Effects of prenatal multimicronutrient supplementation on pregnancy outcomes: a meta-analysis

AUTHOR(S)
Shah, Prakesh S.; Ohlsson, Arne
PUB. DATE
June 2009
SOURCE
CMAJ: Canadian Medical Association Journal;6/9/2009, Vol. 180 Issue 12, pE99
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Reduced intake of micronutrients during pregnancy exposes women to nutritional deficiencies and may affect fetal growth. We conducted a systematic review to examine the efficacy of prenatal supplementation with multimicronutrients on pregnancy outcomes. Methods: We searched MEDLINE, EMBASE, CINAHL and the Cochrane Library for relevant articles published in English up to December 2008. We also searched the bibliographies of selected articles as well as clinical trial registries. The primary outcome was low birth weight; secondary outcomes were preterm birth, small-for-gestational-age infants, birth weight and gestational age. Results: We observed a significant reduction in the risk of low birth weight among infants born to women who received multimicronutrients during pregnancy compared with placebo (relative risk [RR] 0.81, 95% confidence interval [CI] 0.73—0.91) or iron—folic acid supplementation (RR 0.83, 95% CI 0.74—0.93). Birth weight was significantly higher among infants whose mothers were in the multimicronutrient group than among those whose mothers received iron—folic acid supplementation (weighted mean difference 54 g, 95% CI 36 g—72 g). There was no significant differences in the risk of preterm birth or small-forgestational- age infants between the 3 study groups. Interpretation: Prenatal multimicronutrient supplementation was associated with a significantly reduced risk of low birth weight and with improved birth weight when compared with iron-folic acid supplementation. There was no significant effect of multimicronutrient supplementation on the risk of preterm birth or small-for-gestational-age infants.
ACCESSION #
40832770

 

Related Articles

  • Maternal nutrition & low birth weight - what is really important? Muthayya, Sumithra // Indian Journal of Medical Research;Nov2009, Vol. 130 Issue 5, p600 

    The prevalence of low birth weight (LBW) is higher in Asia than elsewhere, predominantly because of undernutrition of the mother prior to and during pregnancy. There are qualitative differences in dietary requirements during early and late pregnancy - micronutrients and proteins required in...

  • The association between maternal dietary micronutrient intake and neonatal anthropometry - secondary analysis from the ROLO study. Horan, Mary K.; McGowan, Ciara A.; Gibney, Eileen R.; Donnelly, Jean M.; McAuliffe, Fionnuala M. // Nutrition Journal;10/8/2015, Vol. 14 Issue 1, p1 

    Background: Micronutrients are necessary for fetal growth. However increasingly pregnant women are nutritionally replete and little is known about the effect of maternal micronutrient intakes on fetal adiposity in mothers with increased BMI. The aim of this study was to examine the...

  • Multiple Micronutrient Supplements will not Reduce Incidence of Low Birthweight. Kapil, Umesh // Indian Journal of Community Medicine;Apr2009, Vol. 34 Issue 2, p85 

    The author claims that multiple micronutrient supplement will not reduce incidence of low birth weight (LBW) in India. The author cites the prevalence of micronutrient deficiencies among pregnant women in low-income countries, including the nation. The author notes that about 58.7% of pregnant...

  • Comparative Development of Surviving Co-Twins of Vanishing Twin Conceptions, Twins and Singletons. Anand, Dhullipala; Platt, Mary Jane; Pharoah, Peter O. D. // Twin Research & Human Genetics;Feb2007, Vol. 10 Issue 1, p210 

    Early loss of one fetus in a multiple gestation as a ‘vanishing’ twin is a well recognized phenomenon. It is uncertain whether this has an impact on the development of the surviving co-twin. The aim of this study is to compare the development of singletons, twins and the surviving...

  • Oxidative stress markers and micronutrients in maternal and cord blood in relation to neonatal outcome. Weber, D; Stuetz, W; Bernhard, W; Franz, A; Raith, M; Grune, T; Breusing, N // European Journal of Clinical Nutrition;Feb2014, Vol. 68 Issue 2, p215 

    Background/objectives:Oxidative stress and micronutrient deficiencies have been related to lower birth weight (BW), small for gestational age (SGA) offspring and preterm delivery.Subjects/methods:The relation between neonatal outcome (BW, head circumference, SGA, preterm delivery) with markers...

  • Prenatal micronutrient supplementation: Are we there yet? Bhutta, Zulfiqar A.; Haider, Batool Azra // CMAJ: Canadian Medical Association Journal;6/9/2009, Vol. 180 Issue 12, p1188 

    In this article the authors discuss the systematic review of P.S. Shah and A. Ohlsson on the effect of supplementation with multiple micronutrients on birth weight, low-birth-weight infants, and preterm birth. It notes on the failure of the researchers to analyze the nutritional status of...

  • Programmatic effects of a large-scale multiple-micronutrient supplementation trial in Indonesia: Using community facilitators as intermediaries for behavior change. Shankar, Anita V.; Asrilla, Zaitu; Kadha, Josephine K.; Sebayang, Susy; Apriatni, Mandri; Sulastri, An; Sunarsih, Euis; Shankar, Anuraj H. // Food & Nutrition Bulletin;Jun2009 Supplement, Vol. 30 Issue 2, pS207 

    Background. Clinical trials can serve as an opportunity gateway for enhanced health benefits to the target population, above and beyond the specific intervention being tested. Objective. The Supplementation with Multiple Micronutrients Intervention Trial (SUMMIT), a randomized, controlled...

  • Micronutrient Levels and Supplement Intake in Pregnancy after Bariatric Surgery: A Prospective Cohort Study. Devlieger, Roland; Guelinckx, Isabelle; Jans, Goele; Voets, Willy; Vanholsbeke, Caroline; Vansant, Greet // PLoS ONE;Dec2014, Vol. 9 Issue 12, p1 

    Background: Studies report frequent micronutrient deficiencies after bariatric surgery, but less is known about micronutrient levels of pregnant women after bariatric surgery. Objective: To prospectively evaluate micronutrient levels and supplement intake in pregnancy following bariatric...

  • Effects of Prenatal Multiple Micronutrient Supplementation on Fetal Growth Factors: A Cluster-Randomized, Controlled Trial in Rural Bangladesh. Gernand, Alison D.; Schulze, Kerry J.; Nanayakkara-Bind, Ashika; Arguello, Margia; Shamim, Abu Ahmed; Ali, Hasmot; Wu, Lee; Jr.West, Keith P.; Christian, Parul // PLoS ONE;10/2/2015, Vol. 10 Issue 10, p1 

    Prenatal multiple micronutrient (MM) supplementation improves birth weight through increased fetal growth and gestational age, but whether maternal or fetal growth factors are involved is unclear. Our objective was to examine the effect of prenatal MM supplementation on intrauterine growth...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics