TITLE

Helicobacter pylori Eradication and Gastric Cancer: When Is the Horse Out of the Barn?

AUTHOR(S)
de Vries, A. C.; Kuipers, E. J.; Rauws, E. A. J.
PUB. DATE
June 2009
SOURCE
American Journal of Gastroenterology;Jun2009, Vol. 104 Issue 6, p1342
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Helicobacter pylori infection is a major risk factor for gastric cancer development. Therefore, H. pylori eradication may be an important approach in the prevention of gastric cancer. However, long-term data proving the efficacy of this approach are lacking. This report describes two patients who developed gastric cancer at, respectively, 4 and 14 years after H. pylori eradication therapy. These patients were included in a study cohort of H. pylori-infected subjects who received anti-H. pylori therapy during the early years of development of H. pylori eradication therapy and underwent strict endoscopic follow-up for several years. In both patients, gastric ulcer disease and premalignant gastric lesions, i.e., intestinal metaplasia at baseline and dysplasia during follow-up, were diagnosed before gastric cancer development. These case reports demonstrate that H. pylori eradication does not prevent gastric cancer development in all infected patients after long-term follow-up. In patients with premalignant gastric lesions, in particular in patients with a history of gastric ulcer disease, adequate endoscopic follow-up is essential for early detection of gastric neoplasia.Am J Gastroenterol 2009; 104:1342–1345; doi:10.1038/ajg.2008.15
ACCESSION #
40737278

 

Related Articles

  • Helicobacter pylori eradication versus prokinetics in the treatment of functional dyspepsia: a randomized, double-blind study. Ang, Tiing Leong; Fock, Kwong Ming; Teo, Eng Kiong; Chan, Yiong Huak; Ng, Tay Meng; Chua, Tju Siang; Tan, Jessica Yi-Lyn // Journal of Gastroenterology;Jul2006, Vol. 41 Issue 7, p647 

    This randomized, double-blind study compared the efficacy of Helicobacter pylori eradication against prokinetics in H. pylori-infected functional dyspepsia patients. Patients with moderately severe or severe dyspepsia fulfilling the Rome II criteria were randomized to either H. pylori...

  • Barrett's Ulcer: The Clinical Significance Today. Komorowski, Richard A.; Hogan, Walter J.; Chausow, Douglas D. // American Journal of Gastroenterology;Nov1996, Vol. 91 Issue 11, p2310 

    Objectives: The present day clinical significance and natural history of Barrett's esophageal ulcer are compared with those reported originally by Barrett. Methods: Records of patients with Barrett's ulcers followed by the Gastroenterology Service at the Medical College of Wisconsin were...

  • HEPATOCELLULAR CARCINOMA IN ARTERIOHEPATIC DYSPLASIA. Keeffe, Ëmmet B.; Pinson, C. W.; Ragsdale, John; Zonana, Jonathan // American Journal of Gastroenterology;Sep1993, Vol. 88 Issue 9, p1446 

    Reports on cases of hepatocellular carcinoma in arteriohepatic dysplasia (AD). Features of AD; Association between AD and hepatocellular carcinoma; Occurrence of tumors in patients.

  • Treatment of functional dyspepsia: where to go and what to do. Oshima, Tadayuki; Miwa, Hiroto // Journal of Gastroenterology;Jul2006, Vol. 41 Issue 7, p718 

    The article discusses a research on the treatment of functional dyspepsia. In reference to a study by T.L. Ang and colleagues in this same issue. It found that Helicobacter pylori eradication and prokinetic therapy resulted in symptom improvement in more than 60 percent of functional dyspepsia...

  • Dyspepsia and Helicobacter pylori Infection. Syam, Ari Fahrial // Indonesian Journal of Gastroenterology, Hepatology & Digestive E;Apr2015, Vol. 15 Issue 1, p1 

    No abstract available.

  • Infantile hypertrophic pyloric stenosis: an infectious cause? Sherwood, W.; Choudhry, M.; Lakhoo, K. // Pediatric Surgery International;Jan2007, Vol. 23 Issue 1, p61 

    The aetiology of infantile hypertrophic pyloric stenosis (IHPS) remains unclear. The aim of this study was to test the hypothesis that a common bacterium, Helicobacter pylori (HP) may be implicated in the pathogenesis of IHPS. Thirty-nine consecutive infants with confirmed IHPS had their stool...

  • Prevalence of Helicobacter pylori in Gastric Hyperplastic Polyps. Horvath, Bela; Pai, Rish K. // International Journal of Surgical Pathology;Dec2016, Vol. 24 Issue 8, p704 

    Hyperplastic polyps of the stomach are routinely encountered during upper endoscopy and often arise in the setting of abnormal surrounding mucosa, particularly Helicobacter pylori, autoimmune gastritis, and reactive gastropathy. Not infrequently gastroenterologists fail to biopsy the surrounding...

  • The viable but nonculturable state of Helicobacter pylori. Bates, T.C.; Adams, B.L.; Oliver, J.D. // Gut;Sep2002 Supplement 2, Vol. 51, pA5 

    The main etiological agent for chronic human gastritis and peptic ulcers is Helicobacter pylori. Despite such a high incidence of infection, this bacterium's reservoir(s) and the route of transmission remain undetermined. Epidemiological evidence suggests that these organisms may be waterborne...

  • Accuracy of the stool antigen test for the diagnosis of childhood Helicobacter pylori infection: a multicenter Japanese study Kato, Seiichi; Ozawa, Kyoko; Okuda, Masumi; Fujisawa, Takuji; Kagimoto, Seiichi; Konno, Mutsuko; Maisawa, Shunichi; Iinuma, Kazuie // American Journal of Gastroenterology;Feb2003, Vol. 98 Issue 2, p296 

    : ObjectiveThe 13C-urea breath test (UBT) has been accepted as a reliable noninvasive test for detecting Helicobacter pylori infection. Recently, another noninvasive test, a new enzyme immunoassay for H. pylori antigens in stool, has been widely investigated for its clinical usefulness. The...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics