TITLE

A Meta-Analysis of the Diagnostic Accuracy of Esophageal Capsule Endoscopy for Barrett's Esophagus in Patients With Gastroesophageal Reflux Disease

AUTHOR(S)
Bhardwaj, Atul; Hollenbeak, Christopher S.; Pooran, Nakechand; Mathew, Abraham
PUB. DATE
June 2009
SOURCE
American Journal of Gastroenterology;Jun2009, Vol. 104 Issue 6, p1533
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVES:To evaluate the diagnostic accuracy of esophageal capsule endoscopy (ECE) for Barrett's esophagus (BE) in patients with gastroesophageal reflux disease (GERD).METHODS:Literature was searched for blinded studies evaluating the diagnostic accuracy of ECE for BE in patients with GERD. Meta-analysis was carried out to calculate pooled sensitivity and specificity of ECE for diagnosis of BE. Subgroup analysis was also carried out based on the reference standard used.RESULTS:Nine studies comprising a total of 618 patients met the inclusion criteria. The pooled sensitivity and specificity of ECE for the diagnosis of BE for all studies were 77 and 86% respectively. The pooled sensitivity and specificity of ECE for the diagnosis of BE using esophagogastroduodenoscopy (EGD) as the reference standard were 78 and 90%, respectively; using histologically confirmed intestinal metaplasia (IM) as the reference standard pooled sensitivity and specificity were 78 and 73%, respectively. Statistical heterogeneity was not evident among studies for sensitivity results (P=0.270, I2=19), but heterogeneity was present for specificity results (P<0.001, I2=74). There was no evidence of publication bias. The ECE was found to be safe and had a high rate of patient preference.CONCLUSIONS:Capsule endoscopy of esophagus has a moderate sensitivity and specificity for the diagnosis of BE in patients with GERD. The EGD remains the modality of choice for evaluation of suspected BE.Am J Gastroenterol 2009; 104:1533–1539; doi:10.1038/ajg.2009.86; published online 21 April 2009
ACCESSION #
40737220

 

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