TITLE

Antifungals: Need to Search for a New Molecular Target

AUTHOR(S)
SANGAMWAR, A. T.; DESHPANDE, U. D.; PEKAMWAR, S. S.
PUB. DATE
July 2008
SOURCE
Indian Journal of Pharmaceutical Sciences;2008, Vol. 70 Issue 4, p423
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In the 1990s, drug resistance has become an important problem in a variety of infectious diseases including human immunodefi ciency virus infection, tuberculosis, and other bacterial infections which have profound effects on human health. At the same time, there have been dramatic increase in the incidence of fungal infections, which are probably the result of alterations in immune status associated with the acquired immuno defi ciency syndrome epidemic, cancer chemotherapy, and organ and bone marrow transplantation. The rise in the incidence of fungal infections has exacerbated the need for the next generation of antifungal agents, since many of the currently available drugs have undesirable side effects, are ineffective against new or reemerging fungi, or lead to the rapid development of the resistance. This review will focus on the pathogenic yeast Candida albicans, since a large body of work on the factors and mechanism associated with antifungal drug resistance in this organism is reported suffi ciently. It will certainly elaborate the probable molecular targets for drug design, discovered to date.
ACCESSION #
40625214

 

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