TITLE

Syndrome of inappropriate antidiuretic hormone secretion associated with acute myeloid leukemia with multilineage dysplasia

AUTHOR(S)
Shoko Nakayama; Taiji Yokote; Kichinosuke Kobayashi; Yuji Hirata; Toshikazu Akioka; Takuji Miyoshi; Takayuki Takubo; Motomu Tsuji; Toshiaki Hanafusa
PUB. DATE
June 2009
SOURCE
Endocrine (1355008X);Jun2009, Vol. 35 Issue 3, p290
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract  A patient having acute myeloid leukemia (AML) with multilineage dysplasia, developed hyponatremia and showed all symptoms of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) through a mechanism similar to tumor lysis. Retrospective immunohistochemical analysis of blast cells was positive for antidiuretic hormone (ADH) protein. According to us, this is the first case report of SIADH in an AML patient with multilineage dysplasia, showing blast cells immunostained for ADH, which clearly demonstrated that the tumor cells produced ADH.
ACCESSION #
40419561

 

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