Association of TRB3 gene Q84R polymorphism with type 2 diabetes mellitus in Chinese population

Zhiyong Shi; Jing Liu; Qian Guo; Xiaoqin Ma; Linna Shen; Sanni Xu; Hongxia Gao; Xinjian Yuan; Junling Zhang
June 2009
Endocrine (1355008X);Jun2009, Vol. 35 Issue 3, p414
Academic Journal
Abstract   Background TRB3, a human homolog of Drosophila Tribbles, has been shown as a critical negative regulator of Akt (also known as protein kinase B), which is a key component in insulin signaling. In addition, TRB3 is another PPAR-target gene and functions as an important link between glucose and lipid metabolism. The Q84R polymorphic variant of TRB3 has been linked to insulin resistance and related clinical outcomes. However, it is unclear whether this polymorphism is associated with type 2 diabetes mellitus (T2DM) in the Chinese population. Methods In this study, we genotyped Q84R polymorphism in 177 patients with T2DM and 245 control subjects in Chinese population by using the polymerase chain reaction/ligase detection reaction (PCR/LDR) assay. Results No significant difference in the Q84R genotype frequency was observed between T2DM patients and controls (P = 0.642). In T2DM group, the Q84R variant in cases was associated with higher FINS, higher HOMA-IR, and lower LnISI (P = 0.003, 0.001, and 0.001, respectively). However, the changes in HOMA-IR and LnISI were not significant in controls (the P value is 0.098 and 0.203, respectively). In addition, FINS levels were also significantly increased from Q84Q to R84 in controls (P = 0.036). Conclusion Our data indicate that the TRB3 Q84R polymorphism is not associated with T2DM in Chinese population. However, the Q84R variant is associated with insulin resistance among T2DM patients in Chinese population.


Related Articles

  • The Correlation between the CLEC16A Gene and Genetic Susceptibility to Type 1 Diabetes in Chinese Children. Yanmei Sang; Wei Zong; Jie Yan; Min Liu // International Journal of Endocrinology;2012, p1 

    Objective. The CLEC16A gene is related to the genetic susceptibility to T1DM with racial variability. This study investigated the association between CLEC16A gene polymorphisms and T1DM in Chinese children. Methods. 131 Chinese children with T1DM were selected for study, and 121 healthy adult...

  • The LRP6 rs2302685 polymorphism is associated with increased risk of myocardial infarction. Shun Xu; Jie Cheng; Yu-ning Chen; Keshen Li; Ze-wei Ma; Jin-ming Cen; Xinguang Liu; Xi-li Yang; Can Chen; Xing-dong Xiong // Lipids in Health & Disease;2014, Vol. 13 Issue 1, p1 

    Background Abnormal lipids is one of the critical risk factors for myocardial infarction (MI), however the role of genetic variants in lipid metabolism-related genes on MI pathogenesis still requires further investigation. We herein genotyped three SNPs (LRP6 rs2302685, LDLRAP1 rs6687605, SOAT1...

  • APOE and LRPAP1 gene polymorphism and risk of Parkinson's disease. Singh, Neeraj; Banerjee, Basu; Bala, Kiran; Mitrabasu; Dung Dung, Aldrin; Chhillar, Neelam // Neurological Sciences;Jul2014, Vol. 35 Issue 7, p1075 

    Epidemiologic findings suggest that lipids and alteration in lipid metabolizing protein/gene may contribute to the development of neurodegenerative disorders. The aim of the current study was to determine the serum lipid levels and genetic variation in two lipid metabolizing genes, low-density...

  • T2DM-GeneMiner a web resource for meta-analysis and marker identification for type 2 diabetes mellitus. Rasche, Axel; Herwig, Ralf // BMC Bioinformatics;2007 Supplement 8, Vol. 8, Special section p1 

    Background Multiple functional genomics data for complex human diseases have been published and made available by researchers worldwide. Main goal of these studies is the detailed analysis of a particular aspect of the disease. Recently, meta-analysis approaches have been published that try to...

  • The rs3917779 polymorphism of P-selectin's significant association with proliferative diabetic retinopathy in Yazd, Iran. Kolahdouz, Parisa; Farashahi Yazd, Ehsan; Tajamolian, Masoud; Manaviat, Masoud; Sheikhha, Mohammad // Graefe's Archive of Clinical & Experimental Ophthalmology;Nov2015, Vol. 253 Issue 11, p1967 

    Purpose: This study aims at investigating possible associations of P-selectin polymorphisms with proliferative diabetic retinopathy (PDR) in Yazd, Iran. Methods: The subjects of the study included of 55 PDR and 55 diabetic no retinopathy (DNR) cases attending Yazd Diabetes Research Center...

  • Rapid Discrimination of Salmonella Isolates by Single-Strand Conformation Polymorphism Analysis. AL-ADHAMI, BATOL H.; HUBY-CHILTON, FLORENCE; BLAIS, BURTON W.; MARTINEZ-PEREZ, AMALIA; CHILTON, NElL B.; GAJADHAR, ALVIN A. // Journal of Food Protection;Oct2008, Vol. 71 Issue 10, p1960 

    A molecular typing technique was developed for the differentiation of Salmonella isolates based on single-strand conformation polymorphism (SSCP) analysis of amplicons generated by PCR. Amplicons from parts of the fimA (both the 5' and 3' ends), mdh, invA, and atpD genes were generated...

  • High polymorphism and resolution in targeted fingerprinting with combined β-tubulin introns. Breviario, Diego; Baird, Wm.; Sangoi, Shail; Hilu, Khidir; Blumetti, Pietro; Gianì, Silvia // Molecular Breeding;Oct2007, Vol. 20 Issue 3, p249 

    Tubulin-Based-Polymorphism (TBP) was originally introduced as a novel method for assaying genetic diversity in plants. TBP is based on polymorphism resulting from the PCR-mediated amplification of the first intron in the coding region of the β-tubulin gene family. Although, the method was...

  • Association Between Gene Polymorphisms of IRAK-M and the Susceptibility of Sepsis. Dong, Gao-hong; Gong, Jian-ping; Li, Jin-zheng; Luo, Yu-hong; Li, Zhen-dong; Li, Pei-zhi; He, Kun // Inflammation;Oct2013, Vol. 36 Issue 5, p1087 

    The aim of this study was to explore the association between the single-nucleotide polymorphisms of interleukin-1 receptor-associated kinase-M (IRAK-M) gene and the susceptibility of sepsis. The allele frequency and genotype distribution of IRAK-M gene polymorphisms were assessed in 118 controls...

  • The Single Nucleotide Polymorphisms of Kir3.4 Gene and Their Correlation with Lone Paroxysmal Atrial Fibrillation in Chinese Han Population Zhang, Chuan; Yuan, Gao-Hui; Cheng, Zhen-Feng; Xu, Min-Wen; Hou, Li-fang; Wei, Fan-Ping // Heart, Lung & Circulation;Aug2009, Vol. 18 Issue 4, p257 

    Background: Acetylcholine induced inwardly rectifying current (I KACh) is a heteromultimeric complex formed by Kir3.1 and Kir3.4 subunits and plays important roles in the development of atrial fibrillation (AF). AF is a common disorder among Chinese, the frequency of AF is about 0.61%, and in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics