TITLE

Regulatory T cells in type 1 diabetic patients with autoimmune chronic atrophic gastritis

AUTHOR(S)
José Mate
PUB. DATE
June 2009
SOURCE
Endocrine (1355008X);Jun2009, Vol. 35 Issue 3, p420
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Abstract  Type A chronic atrophic gastritis (CAG) is increased in type 1 diabetic patients (DM1). To address this issue, we determined and analyzed the number of peripheral blood regulatory T cells (Tregs) in 15 DM1-CAG patients, 15 DM1 patients without associated autoantibodies (DM1) and 15 healthy controls by flow cytometry and compared gastric Tregs expression (CD4+Foxp3+/CD4+) in DM1-CAG patients with that observed in 10 control Helicobacter pylori CAG-infected biopsies. The percentage of peripheral Tregs was higher in DM1-CAG patients compared to DM1 and controls (CD4+Foxp3+: 7.67 ± 1.91% vs. 5.38 ± 1.57% and 5.65 ± 1.76%, P H. pylori CAG than in DM1-CAG patients (31.31 ± 5.52% vs. 7.68 ± 3.70%; P 
ACCESSION #
40419548

 

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