Interaction of environmental factors in oesophageal carcinogenesis

Manjunath, S.; Jankowski, J.A.Z
August 2000
Journal of the Royal College of Surgeons of Edinburgh;Aug2000, Vol. 45 Issue 4, p260
Academic Journal
Indicates that the interaction between the various environmental factors with genetic susceptibility seems to result in predictable succession of events following an esophagitis-metaplasia-dyspepsia-carcinoma sequence. Incidence of adenocarcinoma of the esophagus; Squamous cell carcinoma of the esophagus.


Related Articles

  • Review on novel concepts of columnar lined esophagus. Lenglinger, Johannes; See, Stephanie Fischer; Beller, Lukas; Cosentini, Enrico P.; Asari, Reza; Wrba, Fritz; Riegler, Martin; Schoppmann, Sebastian F. // Wiener Klinische Wochenschrift;Oct2013, Vol. 125 Issue 19/20, p577 

    Background: Columnar lined esophagus (CLE) is a marker for gastroesophageal reflux and associates with an increased cancer risk among those with Barrett's esophagus. Recent studies fostered the development of integrated CLE concepts. Methods: Using PubMed, we conducted a review of studies on...

  • Magnification Endoscopy and Chromoendoscopy in Evaluation of Specialized Intestinal Metaplasia in Barrett's Esophagus. Wasielica-Berger, Justyna; Baniukiewicz, Andrzej; Wroblewski, Eugeniusz; Chwiesko, Adam; Dabrowski, Andrzej // Digestive Diseases & Sciences;Jul2011, Vol. 56 Issue 7, p1987 

    Background: Specialized intestinal metaplasia (SIM) in Barrett's esophagus is a risk factor of esophageal adenocarcinoma. It often occurs focally and cannot be distinguished from surrounding columnar epithelium with conventional endoscopy. Aims: The purpose of this study was evaluation of...

  • Genetic susceptibility to esophageal cancer: the role of the nucleotide excision repair pathway. Pan, Jennifer; Lin, Jie; Izzo, Julie G.; Liu, Yang; Xing, Jinliang; Huang, Maosheng; Ajani, Jaffer A.; Wu, Xifeng // Carcinogenesis;May2009, Vol. 30 Issue 5, p785 

    In this case–control study with 387 White esophageal patients and 462 White controls matched to cases by age and sex, we evaluated the associations between 13 potential functional polymorphisms in eight major nucleotide excision repair (NER) genes and esophageal cancer risk. In...

  • A prospective cohort study of obesity and risk of oesophageal and gastric adenocarcinoma in the NIHeAARP Diet and Health Study. O'Doherty, Mark G.; Freedman, Neal D.; Hollenbeck, Albert R.; Schatzkin, Arthur; Abnet, Christian C. // Gut;Sep2012, Vol. 61 Issue 9, p1261 

    Objective The incidence of oesophageal adenocarcinoma (EAC) has increased rapidly over the past 40 years and accumulating evidence suggests that obesity, as measured by body mass index (BMI), is a major risk factor. It remains unclear whether abdominal obesity is associated with EAC and gastric...

  • Risk of oesophageal cancer by histology among patients hospitalised for gastroduodenal ulcers. Bahmanyar, Shahram; Zendehdel, Kazem; Nyrén, Olof; Weimin Ye // Gut;Apr2007, Vol. 56 Issue 4, p464 

    Objective: The mechanism behind the epidemiologically evident inverse relation between Helicobacter pylori seropositivity and risk of oesophageal adenocarcinoma (OAC) remains obscure. Severe corpus gastritis is unlikely to be in the causal pathway. With the hypothesis of a uniformly low risk,...

  • Esophageal Cancer in Iran: A Review. Sadjadi, Alireza; Marjani, Hajiamin; Semnani, Shahryar; Nasseri-Moghaddam, Siavosh // Middle East Journal of Cancer;2010, Vol. 1 Issue 1, p5 

    Esophageal cancer is the second and third most common malignancy in Iranian males and females, respectively, claiming lives of approximately 5800 Iranians each year. Squamous cell carcinoma (SCC) is presently the most common type accounting for about 90% of all esophageal cancers in Iran. Recent...

  • Managing Barrett's oesophagus. Spechler, Stuart Jon // BMJ: British Medical Journal (International Edition);4/26/2003, Vol. 326 Issue 7395, p892 

    Editorial. Focuses on what to do so Barrett's esophagus will not turn into esophageal cancer. Conditions of chronic gastro-esophageal reflux disease (GORD) that lead to Barrett's esophagus; Discussion of the development and prognosis for esophageal adenocarcinoma; Management strategies to...

  • Recent epidemiological studies in Sweden. Nyren, O. // Journal of the Royal College of Surgeons of Edinburgh;Aug2000, Vol. 45 Issue 4, p260 

    Features a population-based case-control study of risk factors for cancers of the esophagus and gastroesophageal junction in Sweden. Increased incidence of adenocarcinomas in western populations; Association between Barrett's esophagus and gastroesophageal reflux disease.

  • The relation of gastroesophageal reflux disease and its treatment to adenocarcinomas of the... Chow, Wong-Ho; Finkle, William D. // JAMA: Journal of the American Medical Association;8/9/95, Vol. 274 Issue 6, p474 

    Examines the relationship of gastrointestinal disorders and their treatment to the risk of adenocarcinomas of the esophagus and gastric cardia (AEC). Outcome measures; Odds ratios for adenocarcinoma of the esophagus and gastric cardia; Relationship of adenocarcinoma with use of H2 antagonists...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics