Islet transplantation in type 1 diabetes mellitus

Kovacs, Katherine A.; Farquhar, Donald
January 2001
CMAJ: Canadian Medical Association Journal;1/23/2001, Vol. 164 Issue 2, p255
Academic Journal
Presents a study on Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. Design; Results; Conclusion.


Related Articles

  • Islet Cell Transplantation. Bertuzzi, Federico; Marzorati, Simona; Secchi, Antonio // Current Molecular Medicine;Jun2006, Vol. 6 Issue 4, p369 

    Islet cell transplantation is an attractive alternative therapy to conventional insulin treatment or vascularized whole pancreas transplantation for type 1 diabetic patients. It represents a successful example of somatic cell therapy in humans based on complex procedures for islet isolation from...

  • ISLET CELL TRANSPLANTATION IS IT THE ANSWER WE HOPE IT IS? Barrett, Janet // Countdown;Summer2002, Vol. 23 Issue 3, p16 

    Focuses on issues related to islet cell transplantation. Risk associated with islet transplantation and immunosuppressants; Source of islet cells; Effects of cell transplantation on type 1 diabetes.

  • The impact of the mTOR inhibitor sirolimus on the proliferation and function of pancreatic islets and ductal cells. Bussiere, C. T.; Lakey, J. R. T.; Shapiro, A. M. J.; Korbutt, G. S. // Diabetologia;Oct2006, Vol. 49 Issue 10, p2341 

    The Edmonton Protocol for islet transplantation has provided hope for type 1 diabetic patients. However, this protocol requires lifelong immunosuppression, specifically sirolimus, a cellular antiproliferate. The effect of sirolimus on human pancreatic ductal cells (HDCs) is not known. This may...

  • Risk of Posttransplant Allosensitization in Clinical Islet Allograft Recipients. Cardani, Roberta; Pileggi, Antonello; Baidal, David A.; Ponte, Gaston; Cure, Pablo; Faradji, Raquel N.; Froud, Tatiana; Esquenazi, Violet; Gomez, Carmen; Selvaggi, Gennaro; Ricordi, Camillo; Alejandro, Rodolfo // Diabetes;Jun2007 Supplement 1, Vol. 56, pA45 

    The role of anti-donor HLA sensitization testing in islet rejection still remains unanswered. In order to evaluate the development and significance of alloantibodies in clinical islet transplantation we performed a retrospective analysis of allosensitization on a cohort of 66 patients with T1D...

  • Management of Diabetes.  // Current Medical Literature: Diabetes;2006, Vol. 23 Issue 1, p25 

    The article presents abstracts research on management of diabetes. These include "Islet Transplantation in Type 1 Diabetes Mellitus Using Cultured Islets and Steroid-Free Immunosuppression: Miami Experience," by T. Froud, C. Ricordi, and D. A. Baidal, "The Effect of Low-Dose Atorvastatin on...

  • Pancreatic islet autotransplantation with total pancreatectomy for chronic pancreatitis. Kuroki, Tamotsu; Adachi, Tomohiko; Ono, Shinichiro; Tanaka, Takayuki; Kitasato, Amane; Eguchi, Susumu // Surgery Today;Jul2013, Vol. 43 Issue 7, p715 

    Achieving pain relief and improving the quality of life are the main targets of treatment for patients with chronic pancreatitis. The use of total pancreatectomy to treat chronic pancreatitis is a radical and in some ways ideal strategy. However, total pancreatectomy is associated with severe...

  • Antigen-Specific Dependence of Tr1-Cell Therapy in Preclinical Models of Islet Transplant. Gagliani, Nicola; Jofra, Tatiana; Stabilini, Angela; Valle, Andrea; Atkinson, Mark; Roncarolo, Maria-Grazia; Battaglia, Manuela // Diabetes;Feb2010, Vol. 59 Issue 2, p433 

    OBJECTIVE--In type 1 diabetes, allogeneic pancreatic islet transplant restores insulin production, but life-threatening immunosuppression is required to avoid graft rejection. Induction of antigen (Ag)-specific tolerance by cell therapy with regulatory T-cells (Tregs) represents an attractive...

  • Graves Hyperthyroidism After Stopping Immunosuppressive Therapy in Type 1 Diabetic Islet Cell Recipients With Pretransplant TPO Autoantibodies. Gillard, Pieter; Huurman, Volkert; Van Der Auwera, Dart; Decallonne, Brigitte; Poppe, Kris; Roep, Dart O.; Gorus, Frans; Mathieu, Chantal; Pipeleers, Daniel; Keymeulen, Bart // Diabetes Care;Oct2009, Vol. 32 Issue 10, p1817 

    OBJECTIVE -- After an initially successful islet cell transplantation, a number of patients return to C-peptide negativity, and therefore immunosuppressive therapy is discontinued. Some are then found to have developed Graves disease. We examined the risk of Graves disease after...

  • Long-Term Metabolic and Immunological Follow-Up of Nonimmunosuppressed Patients With Type 1 Diabetes Treated With Microencapsulated Islet Allografts. BASTA, GIUSEPPE; MONTANUCCI, PIA; LUCA, GIOVANNI; BOSELLI, CARLO; NOYA, GIUSEPPE; BARBARO, BARBARA; QI, MEIRIGENG; KINZER, KATIE P.; OBERHOLZER, JOSÉ; CALAFIORE, RICCARDO // Diabetes Care;Nov2011, Vol. 34 Issue 11, p2406 

    OBJECTIVE--To assess long-term metabolic and immunological follow-up of microencapsulated human islet allografts in nonimmunosuppressed patients with type 1 diabetes (T1DM). RESEARCH DESIGN AND METHODS--Four nonimmunosuppressed patients, with long-standing T1DM, received intraperitoneal...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics