Evaluación del tratamiento con VAMP más radioterapia a campos involucrados, en pacientes pediáricos mexicanos con estadio temprano de linfoma de Hodgkin

Olaya-Vargas, Alberto; Velasco-Hidalgo, Liliana; Rivera-Luna, Roberto; Suastegui, Fabián; Zarco, Amador
January 2009
Boletin Medico del Hospital Infantil de Mexico;ene/feb2009, Vol. 66 Issue 1, p60
Academic Journal
Introduction. Purpose: To evaluate outcome and assess toxicity of patients with early-stage Hodgkin lymphoma treated with VAMP and low-dose involved-field radiation. Methods. Patients with clinical favorable stages Hodgkin lymphoma were treated with 4 cycles of VAMP (vinblastine 6 mg/m²sc, doxorrubicyn 25 mg/m²sc, methotrexate 20 mg/ m²sc, and prednisone 40 mg/m²sc) administrated on day 1 and day 15. And 21.6 Gy involved-fied radiation. The overall survival was estimated using Kaplan-Meier and Cox methods. Results. 17 patients were included, the median age was 7 years. Two patients present progressive disease at 4 and 16 months respectively. The overall survival were 94.12% with follow-up of 66 months (IC 95%), the event-free survival were 88.24% with follow up of 63 months (IC 95%). Conclusions. The combined modality therapy with chemotherapy and involved-field radiation (21.6 Gy) shows a better overall survival. The radiation toxicity was elevated, for that reason we must try to reduce the dose of radiotherapy at 15 Gy in patients with complete response to treatment.


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