Simultaneous Intravitreal and Intracameral Injection of Bevacizumab (Avastin) in Neovascular Glaucoma

Yuzbasioglu, Erdal; Artunay, Ozgur; Rasier, Rifat; Sengul, Alper; Bahcecioglu, Halil
June 2009
Journal of Ocular Pharmacology & Therapeutics;Jun2009, Vol. 25 Issue 3, p259
Academic Journal
Purpose: To report the effects of simultaneous intravitreal and intracameral injection of 1.25 mg bevacizumab (Avastin) in 15 neovascular glaucoma (NVG) cases secondary to iris and/or angle neovascularization. Patients and Methods: The study included 15 eyes of 15 patients (seven women, eight men) with NVG secondary to central retinal vein occlusions (CRVO) or proliferative diabetic retinopathy (PDR). Eight eyes had had CRVO and seven PDR prior to NVG. The severity of neovascularization and peripheric anterior synechiae (PAS) was scored from mild (+) to severe (+++). A total dose of 1.25 mg bevacizumab in 0.05 mL was injected into the vitreous cavity and the same dose of bevacizumab into anterior chamber by sterile 30-gauge needle. Results: After treatment neovascularizations on iris and angle were completely resolved 36 h after injection in all patients. Intraocular pressure (IOP) was decreased under 22 mmHg in six cases without any medication. Six cases need medical treatment to achieve appropriate IOP level. Surgical procedure was necessary in three patients who persist high IOP levels despite completely resolved neovascularizations. Conclusions: Simultaneous intravitreal and intracameral injection of bevacizumab can cause an immediate regression of neovascularization secondary to PDR or CRVO and could be an useful adjuvant to prevent dense PAS formation that lead to persistent IOP increasing.


Related Articles

  • Impact of early rise of intraocular pressure on visual outcome following diabetic vitrectomy. Sharma, Yog Raj; Pruthi, Archna; Azad, Raj Vardhan; Kumar, Atul; Mannan, Rashim // Indian Journal of Ophthalmology;Jan2011, Vol. 59 Issue 1, p37 

    Objective: The objective was to study the incidence and risk factors for an early rise in intraocular pressure (IOP) following pars plana vitrectomy (PPV) for proliferative diabetic retinopathy (PDR) and to correlate its impact on visual outcome. Materials and Methods: This was a longitudinal...

  • The Nerve Trumps the Cornea. Fanelli, James L. // Review of Optometry;10/15/2009 Part 1 of 2, Vol. 146 Issue 10, p91 

    The article presents a study of a 71-year old white male for a diabetic retinal evaluation. In 1997, the patient was first diagnosed of having a type 2 diabetes, and was given medications for his maintenance. Diagnostic examinations of the patient includes slit lamp examinations, measurement of...

  • Role of Inflammation in the Pathogenesis of Diabetic Retinopathy. Abu El-Asrar, Ahmed M. // Middle East African Journal of Ophthalmology;Jan-Mar2012, Vol. 19 Issue 1, p70 

    Diabetic retinopathy (DR) remains a major cause of worldwide preventable blindness. The microvasculature of the retina responds to hyperglycemia through a number of biochemical changes, including activation of protein kinase C, increased advanced glycation end products formation, polyol pathway,...

  • The Role of Angiogenesis in the Development of Proliferative Diabetic Retinopathy: Impact of Intravitreal Anti-VEGF Treatment. Tremolada, Gemma; Turco, Claudia Del; Lattanzio, Rosangela; Maestroni, Silvia; Maestroni, Anna; Bandello, Francesco; Zerbini, Gianpaolo // Experimental Diabetes Research;2012, Special section p1 

    Although cellular and molecular bases of proliferative diabetic retinopathy are only partially understood, it is evident that this complication of diabetes is characterized by the formation of new vessels inside the retina showing abnormal architecture and permeability. This process, if not...

  • Randomised controlled trial of posterior sub-Tenon triamcinolone as adjunct to panretinal photocoagulation for treatment of diabetic retinopathy. N Unoki // British Journal of Ophthalmology;Jun2009, Vol. 93 Issue 6, p765 

    AIMS: To evaluate the efficacy of a single posterior sub-Tenon capsule injection of triamcinolone acetonide (PSTA) before panretinal photocoagulation (PRP). METHODS: This 6-month study involved the randomisation of 82 eyes of 41 patients, with bilateral severe non-proliferative diabetic...

  • SNPs in erythropoietin gene increase risk of diabetic retinopathy, especially in type 2 diabetes.  // Ocular Surgery News;6/25/2010, Vol. 28 Issue 12, p36 

    The article discusses a study which showed that an increase in the risk of diabetic retinopathy and the development of proliferative diabetic retinopathy can be caused by the presence of single nucleotide polymorphisms (SNPs) in the gene for erythropoietin.

  • The incidence of visual impairment due to diabetic retinopathy in Leeds. Kumar, N.; Goyder, E.; McKibbin, M. // Eye;Apr2006, Vol. 20 Issue 4, p455 

    AimA key aim of the photographic screening model for diabetic retinopathy advocated by the National Screening Committee is a reduction in new blindness due to diabetic retinopathy within 5 years. This study determines the incidence of visual impairment due to diabetic retinopathy in Leeds in...

  • Dietary Taurine Supplementation Ameliorates Diabetic Retinopathy via Anti-excitotoxicity of Glutamate in Streptozotocin-induced Sprague-Dawley Rats. Zhaoxia Xu; Mantian Mi; Hongxia Xu; Jundong Zhu; Na Wei; Ka Chen; Qianyong Zhang; Kaihong Zeng; Jian Wang; Fang Chen; Yong Tang // Neurochemical Research;Mar2008, Vol. 33 Issue 3, p500 

    Abstract  The purpose of this study was to investigate whether taurine ameliorate the diabetic retinopathy, and to further explore the underlying mechanisms. The Sprague-Dawley rats were injected with streptozotocin to establish experimental diabetic model, then fed without or...

  • Awareness of diabetic retinopathy largely lacking in those with the disease. Kronemyer, Bob // Endocrine Today;Oct2013, Vol. 11 Issue 10, p16 

    The article discusses the risk factors associated with diabetic retinopathy which include high levels of glycated haemoglobin (HbA1C) and longer duration of diabetes.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics