TITLE

Gene expression and hepatitis C virus infection

AUTHOR(S)
T Asselah
PUB. DATE
June 2009
SOURCE
Gut;Jun2009, Vol. 58 Issue 6, p846
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Hepatitis C virus (HCV) is a major cause of chronic liver disease, with about 170 million people infected worldwide. Up to 70% of patients will have persistent infection after inoculation, making this disease a significant cause of morbidity and mortality. The severity of disease varies widely, from asymptomatic chronic infection to cirrhosis and hepatocellular carcinoma. Since the discovery of HCV, the treatment of hepatitis C has considerably improved. Recently, combination of pegylated interferons with ribavirin gives a response rate of about 55%. Treatment is indicated in patients with moderate or severe fibrosis. The tolerability of combination treatment is relatively poor, with a frequent flu-like syndrome and an impaired quality of life. In addition to viral and environmental behavioural factors, host genetic diversity is believed to contribute to the spectrum of clinical outcomes in HCV infection. The sequencing of the human genome, together with the development of high-throughput technologies that measure the function of the genome, have afforded unique opportunities to develop profiles that can distinguish, identify and classify discrete subsets of disease, predict the disease outcome or predict the response to treatment. This paper reviews the published literature on gene expression associated with HCV infection (HCV infection, fibrosis progression), and also according to response to treatment.
ACCESSION #
39987823

 

Related Articles

  • PRO-C3-Levels in Patients with HIV/HCV-Co-Infection Reflect Fibrosis Stage and Degree of Portal Hypertension. Jansen, Christian; Leeming, Diana J.; Mandorfer, Mattias; Byrjalsen, Inger; Schierwagen, Robert; Schwabl, Philipp; Karsdal, Morten A.; Anadol, Evrim; Strassburg, Christian P.; Rockstroh, Jürgen; Peck-Radosavljevic, Markus; Møller, Søren; Bendtsen, Flemming; Krag, Aleksander; Reiberger, Thomas; Trebicka, Jonel // PLoS ONE;Sep2014, Vol. 9 Issue 9, p1 

    Background: Liver-related deaths represent the leading cause of mortality among patients with HIV/HCV-co-infection, and are mainly related to complications of fibrosis and portal hypertension. In this study, we aimed to evaluate the structural changes by the assessment of extracellular matrix...

  • Cell cycle perturbation in a human hepatoblastoma cell line constitutively expressing Hepatitis C virus core protein. A. Ruggieri; M. Murdolo; T. Harada; T. Miyamura; M. Rapicetta // Archives of Virology;Jan2004, Vol. 149 Issue 1, p61 

    Summary. Hepatitis C virus (HCV) is one of the major causes of chronic liver disease with the potential for development of hepatocellular carcinoma (HCC). The core protein of HCV has been shown to modulate expression of various cellular genes and to influence a number of cellular functions. We...

  • Tissue factor expression on blood monocytes in patients with hepatitis C virus-induced chronic liver disease. El-Bassiouni, N.; El Messery, L.; Zayed, R.; Metwally, O.; Zahran, M.; Mahmoud, O.; Ibrahim, R.; Bassiouny, A. // Comparative Clinical Pathology;Sep2014, Vol. 23 Issue 5, p1159 

    Chronic liver disease (CLD) is a worldwide common pathology characterised by an inflammatory and fibrotic process leading to progressive evolution from chronic hepatitis to cirrhosis. Monocytes play a crucial role in the pathogenesis of inflammation and fibrosis in chronic liver diseases....

  • Alcoholic Liver Disease-Related Mortality in the United States: 1980–2003. Paula, Helga; Asrani, Sumeet K.; Boetticher, Nicholas C.; Pedersen, Rachel; Shah, Vijay H.; Kim, W. Ray // American Journal of Gastroenterology;Aug2010, Vol. 105 Issue 8, p1782 

    OBJECTIVES:Data on temporal changes in alcoholic liver disease (ALD)-related mortality in the United States are lacking. This longitudinal assessment is important, given the divergent data on trends in worldwide ALD-related mortality, concerns for underestimation of mortality attributed to ALD...

  • Gene expression profiling of HCV genotype 3a initial liver fibrosis and cirrhosis patients using microarray.  // Journal of Translational Medicine;2012, Vol. 10 Issue 1, p41 

    The article offers information on the study conducted by the authors related to gene expression profiling of hepatitis C virus (HCV) genotype 3a initial liver fibrosis and cirrhosis patients using microarray. It states that HCV causes liver fibrosis that may lead to liver cirrhosis or...

  • Serum Aminotransferase Levels and Platelet Counts as Predictors of Degree of Fibrosis in Chronic Hepatitis C Virus Infection. Pohl, Annette; Behling, Cynthia; Oliver, Deanna; Kilani, Marwa; Monson, Petrea; Hassanein, Tarek // American Journal of Gastroenterology;Nov2001, Vol. 96 Issue 11, p3142 

    OBJECTIVE: In patients with chronic hepatitis C virus (HCV) infection, liver fibrosis stage is a prognostic factor for therapy outcome. So far, a liver biopsy is necessary to determine disease stage accurately. We sought to develop a simple. noninvasive method of accurately predicting the degree...

  • Accelerated Liver Fibrosis: Two Risk Groups. McCashland, T. M.; Thompson, Jon S. // American Journal of Gastroenterology;Apr2000, Vol. 95 Issue 4, p866 

    Discusses research being done on liver fibrosis. Reference to studies published in a 1999 issue of "Hepatology"; Comparison between patients coinfected by HIV and Hepatitis C virus (HCV) and those infected with HCV only; Predictors of severe fibrosis.

  • Increased miR-16 expression induced by hepatitis C virus infection promotes liver fibrosis through downregulation of hepatocyte growth factor and Smad7. Zhu, Bin; Wei, Xiao-xia; Wang, Tian-bao; Zhou, Yan-cai; Liu, A-min; Zhang, Guang-wen // Archives of Virology;Aug2015, Vol. 160 Issue 8, p2043 

    Hepatitis C virus (HCV) is involved in the initiation and progression of liver fibrosis by regulating genes encoding host proteins. However, the underlying mechanism of HCV-induced liver fibrosis is still to be determined. Reverse transcription polymerase chain reaction (RT-PCR) and western blot...

  • Natural history of hepatitis C recurrence after liver and liver/kidney combined transplantation. Serper, Marina; Levitsky, Josh // Hot Topics in Viral Hepatitis;2012, Vol. 8 Issue 23, p13 

    Hepatitis C virus (HCV) has a very high disease burden worldwide and is currently the leading cause of liver transplantation. Post-transplant reinfection of the liver graft is universal and progression to recurrent hepatitis and fibrosis as well as clinical decompensation can occur at an...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics