Hydrogen sulfide as a novel mediator for pancreatic pain in rodents
- Hydrogen sulphide induces Î¼ opioid
receptor-dependent analgesia in a rodent model
of visceral pain. Distrutti, Eleonora; Cipriani, Sabrina; Renga, Barbara; Mencarelli, Andrea; Migliorati, Marco; Cianetti, Stefano; Fiorucci, Stefano // Molecular Pain;2010, Vol. 6, p36
Background: Hydrogen sulphide (H2S) is a gaseous neuro-mediator that exerts analgesic effects in rodent models of visceral pain by activating KATP channels. A body of evidence support the notion that KATP channels interact with endogenous opioids. Whether H2S-induced analgesia involves opioid...
- Luminal hydrogen sulfide plays a pronociceptive role in mouse colon. M Matsunami // Gut;Jun2009, Vol. 58 Issue 6, p751
OBJECTIVE: Given recent evidence that hydrogen sulfide (H2S), a gasotransmitter, promotes somatic pain through redox modulation of T-type Ca2+channels, the roles of colonic luminal H2S in visceral nociceptive processing in mice were examined. METHODS: After intracolonic administration of NaHS,...
- Upregulation of cystathionine beta-synthetase expression by nuclear factor-kappa B activation contributes to visceral hypersensitivity in adult rats with neonatal maternal deprivation. Li, Lin; Xie, Ruihua; Hu, Shufen; Wang, Yongmeng; Yu, Tianzhu; Xiao, Ying; Jiang, Xinghong; Gu, Jianguo; Hu, Chuang-Ying; Xu, Guang-Yin // Molecular Pain;2012, Vol. 8 Issue 1, p89
Background: Irritable bowel syndrome (IBS) is characterized by chronic visceral hyperalgesia (CVH) that manifested with persistent or recurrent abdominal pain and altered bowel movement. However, the pathogenesis of the CVH remains unknown. The aim of this study was to investigate roles of...
- Role of Hydrogen Sulfide in Severe Burn Injury-Induced Inflammation in Mice. Jing Zhang; Selena Wei Shan Sio; Moochhala, Shabbir; Bhatia, Madhav // Molecular Medicine;Sep/Oct2010, Vol. 16 Issue 9/10, p417
Endogenous hydrogen sulfide (H2S) is naturally synthesized in many types of mammalian cells from L-cysteine in the reactions catalyzed by cystathionine-Î²-synthase and cystathionine-Î³-lyase (CSE). H2S has been demonstrated to play a proinflammatory role in various animal models of hindpaw...
- Biofilter for hydrogen sulfide. Golueke, Clarence // BioCycle;Apr97, Vol. 38 Issue 4, p28
Presents an abstract of the study `Microbial Oxidation of Hydrogen Sulfide with Biofilter,' by Y.C. Chung Chihpin Huan and Ching-Ping Tseng published in the `Journal of Environmental Science and Health' in 1997.
- Hydrogen Sulphide and Pain. Distrutti, Elenora // Inflammation & Allergy - Drug Targets;Apr2011, Vol. 10 Issue 2, p123
No abstract available.
- Effect of hydrogen sulfide (H2S) on rat primary afferent neurons. Miyamoto, Ryo // Japanese Journal of Veterinary Research;Aug2011, Vol. 59 Issue 2/3, p124
The article discusses the impact of hydrogen sulfide (H2S), a toxic gas on rat primary afferent neurons. It analyzes the effect of sodium hydrosulfide (NaHS) on rat dorsal root ganglion (DRG) neurons by using whole-cell voltage-clamp techniques. It concludes that pain sensation can be caused...
- Endogenous CBS-HS Pathway Contributes to the Development of CCI-Induced Neuropathic Pain. Gui, Yulong; Li, Aiyuan; Qiu, Bihui; Chen, Feng; Chen, Liang; Liu, Daming; Chen, Shuxian; Zhou, Wei; Zhou, Hong // Neurochemical Research;Jun2016, Vol. 41 Issue 6, p1381
Studies showed a complex relationship between hydrogen sulfide (HS) and neuropathic pain. In this study, the relationship between endogenous CBS-HS pathway in L spinal cord and neuropathic pain was explored. A total of 163 adult Kunming mice were used in this study. CBS expression and HS...
- desulfhydrase. // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p622
A definition of the term "desulfhydrase," which refers to the enzyme that cleaves cysteine into hydrogen sulfide, ammonia and pyruvic acid, is presented.