Topically Applied Recombinant Chemokine Analogues Fully Protect Macaques from Vaginal Simian-Human Immunodeficiency Virus Challenge

Veazey, Ronald S.; Ling, Binhua; Green, Linda C.; Ribka, Erin P.; Lifson, Jeffrey D.; Piatak Jr., Michael; Lederman, Michael M.; Mosier, Donald; Offord, Robin; Hartley, Oliver
May 2009
Journal of Infectious Diseases;5/15/2009, Vol. 199 Issue 10, p1525
Academic Journal
Effective strategies for preventing human immunodeficiency virus infection are urgently needed, but recent failures in key clinical trials of vaccines and microbicides highlight the need for new approaches validated in relevant animal models. Here, we show that 2 new chemokine (C-C motif) receptor 5 inhibitors, 5P12-RANTES (regulated on activation, normal T cell expressed and secreted) and 6P4-RANTES, fully protect against infection in the rhesus vaginal challenge model. These highly potent molecules, which are amenable to low-cost production, represent promising new additions to the microbicides pipeline.


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