TITLE

Detection of template binding to molecularly imprinted polymers by Raman microspectroscopy

AUTHOR(S)
Kantarovich, Keren; Belmont, Anne-Sophie; Haupt, Karsten; Bar, Ilana; Gheber, Levi A.
PUB. DATE
May 2009
SOURCE
Applied Physics Letters;5/11/2009, Vol. 94 Issue 19, p194103
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We report on sensitive and specific detection and quantification of a template in a molecularly imprinted polymer (MIP) using Raman microspectroscopy. The β-blocking drug S-propranolol and its enantiomer, R-propranolol, were used as target molecules since the selectivity of this MIP is well established and serves as an appropriate validation standard. Specific peaks originating in the template were identified in the Raman spectrum, allowing quantification of bound target molecule. We demonstrate that label-free monitoring can be achieved from volumes as small as 1 μm3 of MIP, based on a single identifying peak.
ACCESSION #
39785807

 

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