TITLE

Nociceptin receptor antagonist JTC-801 inhibits nitrous oxide-induced analgesia in mice

AUTHOR(S)
KOYAMA, TOMOHIRO; FUKUDA, KAZUHIKO
PUB. DATE
May 2009
SOURCE
Journal of Anesthesia;2009, Vol. 23 Issue 2, p301
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The mechanism of the analgesic effect of nitrous oxide (N2O) has not been completely clarified. Although we have reported that the analgesic effect of N2O was significantly decreased in nociceptin-orphanin FQ (N/OFQ) receptor (NOP)-deficient mice, the effect of nociceptin receptor antagonists on N2O-induced analgesia has not been reported. In this investigation, we examined the effect of the NOP antagonist JTC-801 on N2O-induced analgesia in 129Sv mice by the writhing test and tail flick test, and demonstrated that the analgesic effect of N2O was suppressed by the intraperitoneal administration of JTC-801.
ACCESSION #
39656050

 

Related Articles

  • Antagonism of Nitrous Oxide Antinociception in Mice by Intrathecally Administered Antisera to Endogenous Opioid Peptides. Cahill, Francis J.; Ellenberger, Elizabeth A.; Mueller, Janet L.; Tseng, Leon F.; Quock, Raymond M. // Journal of Biomedical Science;2000, Vol. 7 Issue 4, p299 

    Previously it was demonstrated that nitrous oxide antinociception in the mouse abdominal constriction test is mediated by κ-opioid receptors. Since nitrous oxide is thought to cause the neuronal release of endogenous opioid peptide to stimulate opioid receptors, this study was designed to...

  • Use of Entonox® in the community for control of procedural pain. Evans, Andrea // British Journal of Community Nursing;Nov2003, Vol. 8 Issue 11, p488 

    Describes the successful introduction on nitrous oxide/oxygen for control of procedural pain. Recognition of the role of nitrous oxide gas, mixed with oxygen with a 50:50 ratio, as an effective and safe analgesic used in clinical practice; Absence of recognition of the gas for controlling...

  • Guideline on Use of Nitrous Oxide for Pediatric Dental Patients.  // Pediatric Dentistry;2010 Reference Manual, Vol. 32 Issue 6, p163 

    The article presents guidelines from the American Academy of Pediatric Dentistry concerning the use of nitrous oxide/oxygen inhalation for pediatric dental patients. It states that the use of analgesia or anxiolysis can diminish or eliminate pain and anxiety in conscious dental patients who can...

  • Endogenous opioids and pain: a review. Hill, R. G. // Journal of the Royal Society of Medicine;Jun1981, Vol. 74 Issue 6, p448 

    The article examines published studies on the role of endogenous opioids in pain control. It is asserted that at present, there is no suitable drugs that will specifically deplete or lesion opioid peptide-containing neurones that will prevent degradation of released opioid. The only available...

  • Synthesis and analgesic activity of some N-protected dehydrophenylalanine dipeptides. B. Haseena Banu; Bharathi, Prof. K. // Journal of Pharmacy Research;Oct2010, Vol. 3 Issue 10, p2450 

    Peptides are key regulators in cellular and intercellular physiological responses and possess enormous promise for the treatment of pathological conditions. Opioid peptide activity within the central nervous system (CNS) is of particular interest for the treatment of pain owing to the elevated...

  • Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain. Roques, Bernard P.; Fournié-Zaluski, Marie-Claude; Wurm, Michel // Nature Reviews Drug Discovery;Apr2012, Vol. 11 Issue 4, p292 

    Chronic pain remains unsatisfactorily treated, and few novel painkillers have reached the market in the past century. Increasing the levels of the main endogenous opioid peptides - enkephalins - by inhibiting their two inactivating ectopeptidases, neprilysin and aminopeptidase N, has analgesic...

  • enkephalins. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p272 

    An encyclopedia entry for "enkephalins" is presented. It refers to a group of small protein molecules produced in the brain and by nerve endings elsewhere in the body. They have an analgesic effect and are thought to affect mood. They have a slightly different chemical composition when compared...

  • Making Conscious Sedation More Efficient By Custom Made Nasal Hood. Kumar, Pradeep; Aeran, Himanshu; Dhawan, Preeti; Singh, Aditi // Indian Journal of Dental Sciences;Oct2014 Supplemantry, Vol. 6 Issue 4, p018 

    Background: Nitrous oxide was first synthesized in the 1700s. It was inhaled recreationally for the feeling of euphoria it produced. It was not until the mid-1850s that it began to be used as a dental analgesic in England. Nitrous Oxide Oxygen Inhalational Sedation technique is very popular...

  • Development of Opioid Peptide Analogs for Pain Relief. Janecka, A.; Perlikowska, R.; Gach, K.; Wyrebska, A.; Fichna, J. // Current Pharmaceutical Design;3/21/2010, Vol. 16 Issue 9, p1126 

    Opioid receptors and opioid peptides constitute the endogenous opioid system. The most relevant function of the opioid system seems to be the inhibitory modulation of nociceptive information at supraspinal, spinal and peripheral sites, although it is also implicated in the modulation of many...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics